2,3,4,5-四碘-6-[(4-羟基苯基)(4-羰基环己-2,5-二烯-1-亚基)甲基]苯酸二钠 | 18265-54-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,4,5-四碘-6-[(4-羟基苯基)(4-羰基环己-2,5-二烯-1-亚基)甲基]苯酸二钠
• 英文名称: Phentetiothalein sodium
• 英文别名: disodium;2,3,4,5-tetraiodo-6-[(4-oxidophenyl)-(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoate
• CAS: 18265-54-8
• 化学式: C20H8I4Na2O4
• 分子量: 865.9
• InChiKey: LTJJPORGAUSQGH-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.95
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Pharmaceutical combination comprising adenosine A1 receptor antagonists and radiocontrast media
  申请人：Solvay Pharmaceuticals GmbH

  公开号：EP1870093A1

  公开（公告）日：2007-12-26

  The present invention relates to pharmaceutical combinations comprising a therapeutically effective amount of at least one selective adenosine A1 antagonist combined with at least one radiocontrast media. The invention also relates to the use of said combinations in the manufacture of a medicament for the treatment of radiocontrast media induced nephropathy. Furthermore, the invention is relating to a kit comprising a single dosage form of said combination of at least one adenosine A1 antagonist and at least one radiocontrast media.

  本发明涉及由治疗有效量的至少一种选择性腺苷 A1 拮抗剂与至少一种放射性造影剂组合而成的药物组合物。本发明还涉及使用所述组合物制造治疗放射性造影剂诱发的肾病的药物。此外，本发明还涉及一种试剂盒，该试剂盒包含上述至少一种腺苷 A1 拮抗剂和至少一种放射造影剂组合的单一剂型。
• Radiation protection device and methods thereof
  申请人：STEMRAD LTD.

  公开号：US10600524B2

  公开（公告）日：2020-03-24

  A radiation protection device for providing protection of a body part that includes active bone marrow from ionizing radiation may include a radiation protection component configured to be placed adjacent to and externally cover the body part so as to reduce a radiation dose absorbed in that body part.

  用于保护包括活性骨髓在内的身体部位免受电离辐射的辐射防护装置可包括一个辐射防护组件，该组件被配置为放置在身体部位附近并从外部覆盖该身体部位，以减少该身体部位吸收的辐射剂量。
• Multiple hazard protection articles and methods for making them
  申请人：Meridian Research and Development

  公开号：US20040004196A1

  公开（公告）日：2004-01-08

  Articles, including fabrics and film layers, are disclosed which can protect against multiple hazards, including radiation, chemical, biological agents, metal projectiles and fire hazards. In some embodiments, the fabrics and films of the present invention are used to produce garments having protection against multiple hazards and superior heat dissipating properties. A radiation protective compound is preferably created by mixing a radiopaque material, such as barium, bismuth, tungsten or their compounds, with powdered polymer, pelletized polymer or a liquid solution, emulsion or suspension of a polymer in solvent or water. This radiation protective mixture can then be laminated or otherwise adhered to other types of protective films or fabric, such as the protective polymer films or fabrics used for chemical protective garments, biological protective garments, bullet proof vests or fire retardant garments. The principles of this invention can also be applied to a broad range of other articles including surgical hoods, hospital gowns, gloves, patient drapes, partitions, coverings, jumpsuits, ponchos, uniforms, fatigues, tents, probes, envelopes, pouches, wallpaper, liners, drywall, house sidings, house foundations, house roofings etc.

  本发明所公开的物品，包括织物和薄膜层，可抵御多种危害，包括辐射、化学、生物制剂、金属射弹和火灾危害。在某些实施例中，本发明的织物和薄膜可用于生产具有多种危害防护功能和优异散热性能的服装。辐射防护混合物最好是通过将不透射线材料（如钡、铋、钨或其化合物）与粉末状聚合物、颗粒状聚合物或聚合物在溶剂或水中的液态溶液、乳液或悬浮液混合制成。这种防辐射混合物可与其他类型的保护膜或织物，如用于化学防护服、生物防护服、防弹背心或阻燃服的聚合物保护膜或织物进行层压或粘合。本发明的原理还可广泛应用于其他物品，包括外科头罩、病号服、手套、病人帘布、隔板、覆盖物、连体服、披风、制服、疲劳服、帐篷、探针、信封、小袋、墙纸、衬里、干墙、房屋侧墙、房屋地基、房屋屋顶等。
• Radiation detectable and protective articles
  申请人：DeMeo Ronald

  公开号：US20050211930A1

  公开（公告）日：2005-09-29

  Compositions and processes for forming radiopaque polymeric articles are disclosed. In one embodiment, radiation inspection apparatuses and methods are then used to determine the presence and attributes of such radiopaque polymeric articles. A radiopaque polymeric article of the present invention can be created by mixing a radiopaque material, such as barium, bismuth, tungsten or their compounds, with a powdered polymer, pelletized polymer or liquid solution, emulsion or suspension of a polymer in solvent or water. In addition to creating radiation detectable objects, the radiopaque polymeric materials of the present invention can be used to create radiation protective articles, such as radiation protective garments and bomb containment vessels. Enhanced radiation protection can also be achieved through the use of nano-materials. The principals of the present invention can be used to provide protection against other types of hazards, including fire, chemical, biological and projectile hazards.

  公开了用于形成不透射线聚合物品的组合物和工艺。在一个实施方案中，辐射检测装置和方法可用于确定此类不透射线聚合物品的存在和属性。本发明的不透射线聚合物品可通过将不透射线材料（如钡、铋、钨或其化合物）与粉末状聚合物、颗粒状聚合物或聚合物在溶剂或水中的液态溶液、乳液或悬浮液混合而制成。除了制造可探测辐射的物体外，本发明的不透射线聚合物材料还可用于制造辐射防护用品，如辐射防护服和防弹容器。还可以通过使用纳米材料来加强辐射防护。本发明的原理还可用于防护其他类型的危险，包括火灾、化学、生物和射弹危险。
• MULTIPLE HAZARD PROTECTION ARTICLES AND METHODS FOR MAKING THEM
  申请人：Meridian Research and Development

  公开号：EP1547096A2

  公开（公告）日：2005-06-29