Benzamide, 4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-, endo- | 76272-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzamide, 4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-, endo-
• 英文别名: 4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)benzamide
• CAS: 76272-78-1
• 化学式: C₁₆H₂₂ClN₃O₂
• 分子量: 323.82
• InChiKey: HTMNINCXKXABOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia
  申请人：BEECHAM GROUP PLC

  公开号：EP0220011A2

  公开（公告）日：1987-04-29

  A method of treatment of undesirable actions of 5-HT on the gastro-intestinal tract; migraine, cluster headaches and trigeminal neuralgia, cytotoxic agent or radiation induced nausea and vomiting and/or arrhythmia in mammals, including humans, which method comprises administering an efffe- ctive amount of a compound of formula (I) or a pharmaceutic- allv acceptable salt thereof: wherein: R is amino or C1-7 acylamino; X is chloro, bromo or C1-6 alkylthio; and p is 0 or 1; novel compounds within formula (I) wherein X is bromo or C,.6 alkylthio, a process for their preparation and their use as pharmaceuticals.

  一种治疗 5-HT 对胃肠道的不良作用、偏头痛、丛集性头痛和三叉神经痛、细胞毒素或辐射诱发的恶心和呕吐和/或哺乳动物（包括人类）心律失常的方法，该方法包括施用有效量的式（I）化合物或其药学上可接受的盐： 其中 R 是氨基或 C1-7 氨基酰基； X 是氯、溴或 C1-6 烷硫基；以及 p 为 0 或 1；式（I）中的新型化合物 其中 X 为溴代或 C,.6-烷硫基，其制备方法及其作为药物的用途。
• Use of 5-hydroxytryptamine-antagonists in the treatment of mental disorders originating in childhood
  申请人：GLAXO GROUP LIMITED

  公开号：EP0450757A2

  公开（公告）日：1991-10-09

  The invention relates to the use of a compound which acts as an antagonist of 5-HT at 5-HT₃ receptors in the treatment of autism or another disorder originating in childhood in which there is mental retardation.

  本发明涉及一种在 5-HT₃ 受体上作为 5-HT 拮抗剂的化合物在治疗自闭症或另一种源于儿童期的精神发育迟滞疾病中的应用。
• AZABICYCLIC AMIDES OR ESTERS OF HALOGENATED BENZOIC ACIDS
  申请人：BEECHAM GROUP PLC

  公开号：EP0563087A1

  公开（公告）日：1993-10-06
• TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT
  申请人：Dompé S.P.A.

  公开号：EP0712408B1

  公开（公告）日：1998-10-28
• US5225407A
  申请人：——

  公开号：US5225407A

  公开（公告）日：1993-07-06