2-(4-hydroxyphenylamino)-2-phenylacetonitrile | 259235-78-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(4-hydroxyphenylamino)-2-phenylacetonitrile
• 英文别名: 2-((p-hydroxyphenyl)amino)-2-phenylacetonitrile；(4-hydroxy-anilino)-phenyl-acetonitrile；(4-Hydroxy-anilino)-phenyl-acetonitril；α-(4-Oxy-anilino)-phenylessigsaeure-nitril；4-(α-Cyan-benzylamino)-phenol
• CAS: 259235-78-4
• 化学式: C₁₄H₁₂N₂O
• 分子量: 224.262
• InChiKey: QKDQFHWOKOYKPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  56.05
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(4-hydroxyphenylamino)-2-phenylacetonitrile 生成 (4-hydroxy-anilino)-phenyl-acetic acid amide
  参考文献：
  名称：

  Bucherer; Grolee, Chemische Berichte, 1906, vol. 39, p. 992

  摘要：

  DOI：
• 作为产物：
  描述：

  扁桃腈 、 对氨基苯酚 在 丙酮 作用下， 生成 2-(4-hydroxyphenylamino)-2-phenylacetonitrile
  参考文献：
  名称：

  LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE

  摘要：

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.

  DOI：

  10.1016/s0022-5347(05)67701-4

文献信息

• Strecker reactions with hexacyanoferrates as non-toxic cyanide sources
  作者：Caroline Grundke、Till Opatz

  DOI：10.1039/c9gc00720b

  日期：——

  The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium

  斯特雷克反应是应用最广泛的三组分反应。尽管对于制备α-氨基腈，α-氨基酸，乙内酰脲和许多相关化合物非常有用，但是需要使用HCN的有毒来源限制了它在学术和工业环境中的应用。在这里，我们提出了一种简便的方案，可使用亚铁氰化钾和亚铁氰化钾的混合物作为无毒替代物进行Strecker反应。
• Role of (3-aminopropyl)tri alkoxysilanes in grafting of chlorosulphonic acid immobilized magnetic nanoparticles and their application as heterogeneous catalysts for the green synthesis of α-aminonitriles
  作者：Harminder Singh、Jaspreet Kaur Rajput、Priya Arora、Jigyasa Jigyasa

  DOI：10.1039/c6ra20095h

  日期：——

  organic–inorganic hybrid magnetic heterogeneous catalysts. The silanization was carried out on the surface of SiO2 coated Fe3O4 nanoparticles using two different trialkoxy silanes, i.e., 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane (APMES). The effect of the alkoxy silane structure anchored to the surface of silica functionalized Fe3O4 nanoparticles on their surface area and pore volume

  通过接枝硅烷偶联剂对SiO 2包覆的Fe 3 O 4纳米粒子进行表面改性是提高无机磁芯与要固定的有机官能团之间的界面相互作用的非常重要的方法。然而，很少使用有机-无机杂化磁性非均相催化剂研究利用不同的硅烷烷氧基的硅烷接枝分子结构的影响。使用两种不同的三烷氧基硅烷，即在SiO 2包覆的Fe 3 O 4纳米颗粒的表面上进行硅烷化，3-氨基丙基三乙氧基硅烷（APTES）和3-氨基丙基三甲氧基硅烷（APMES）。通过BET分析仪分析了锚固在二氧化硅官能化的Fe 3 O 4纳米颗粒表面上的烷氧基硅烷结构的表面积和孔体积的影响。与APTMS相比，使用APTES进行的硅烷官能化可产生更高的表面积和孔体积。此外，将氯磺酸固定在APTES和APTMS官能化的SiO 2 @Fe 3 O 4上以水为溶剂，一锅合成α-氨基腈，成功地实现了纳米颗粒（AE和AM）的分离，并作为可磁分离的非均相催化剂发挥了作用。使用A
• Shimo, Bulletin of the Chemical Society of Japan, 1926, vol. 1, p. 228
  作者：Shimo

  DOI：——

  日期：——
• SOME DERIVATIVES OF HYDROXYPHENYLGLYCINE. I
  作者：Kotaro Shimo

  DOI：10.1246/bcsj.1.202

  日期：1926.9