5-Allyl-3-(9H-fluoren-9-ylmethyl)-thiazolidine-2,4-dione | 313271-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 5-Allyl-3-(9H-fluoren-9-ylmethyl)-thiazolidine-2,4-dione
• CAS: 313271-25-9
• 化学式: C₂₀H₁₇NO₂S
• 分子量: 335.426
• InChiKey: NSSYDXKQMMESTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  37.38
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  5-Allyl-3-(9H-fluoren-9-ylmethyl)-thiazolidine-2,4-dione 在 jones reagent 、 臭氧 作用下， 生成 [3-(9H-Fluoren-9-ylmethyl)-2,4-dioxo-thiazolidin-5-yl]-acetic acid
  参考文献：
  名称：

  Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands

  摘要：

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00440-6
• 作为产物：
  描述：

  9-芴甲醇 、 5-烯丙基-1,3-噻唑烷-2,4-二酮 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以77%的产率得到5-Allyl-3-(9H-fluoren-9-ylmethyl)-thiazolidine-2,4-dione
  参考文献：
  名称：

  Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands

  摘要：

  Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00440-6