(α-Cyanobenzylidene)-N,N-dimethyl-p-phenylenediamine | 412309-23-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (α-Cyanobenzylidene)-N,N-dimethyl-p-phenylenediamine
• 英文别名: (4-dimethylamino-anilino)-phenyl-acetonitrile；α-(4-Dimethylamino-anilino)-phenylessigsaeure-nitril；N.N-Dimethyl-N'-(α-cyan-benzyl)-p-phenylendiamin；(4-Dimethylamino-anilino)-phenyl-acetonitril
• CAS: 412309-23-0
• 化学式: C₁₆H₁₇N₃
• 分子量: 251.331
• InChiKey: SFSUXISNSFHFDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  39.06
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (α-Cyanobenzylidene)-N,N-dimethyl-p-phenylenediamine 在 硫酸 作用下， 生成 (4-dimethylamino-anilino)-phenyl-acetic acid amide
  参考文献：
  名称：

  LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE

  摘要：

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.

  DOI：

  10.1016/s0022-5347(05)67701-4
• 作为产物：
  描述：

  扁桃腈 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium ethanolate 作用下， 生成 (α-Cyanobenzylidene)-N,N-dimethyl-p-phenylenediamine
  参考文献：
  名称：

  LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE

  摘要：

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.

  DOI：

  10.1016/s0022-5347(05)67701-4

文献信息

• Heterocyclizations of 2-aryl-3-arylamino-4,4,4-trifluoro-2-butenenitrile hydrates to 3-aryl-2-trifluoromethyl-4-quinolones and to 4-N-methylamino-3H-pyrazole-3-spiro-2′-(3′-aryl-3′-trifluoromethyl)oxiranes
  作者：Tarozaemon Nishiwaki、Hirofumi Kikukawa、Takatoshi Kawaji

  DOI：10.1016/0022-1139(94)03201-a

  日期：1995.7

  4-trifluorobutyronitriles and anilines and their structure and heterocyclizations studied. Cyclization with polyphosphoric acid gave poor yields of 3-aryl-2-trifluoromethyl-4-quinolones, but they underwent an interesting cyclization with diazomethane to give a 25%–40% yield of 4-N-methylamino-3H-pyrazole-3-spiro-2′-(3′-aryl-3′-trifluoromethyl)oxiranes. However, the related reaction with diazoethane yielded

  从3-氧代-2-芳基-4,4,4-三氟丁腈和苯胺中获得水合物形式的2-芳基-3-芳基氨基-4,4,4-三氟-2-丁腈，并对其结构和杂环进行了研究。用多磷酸环化产生的3-芳基-2-三氟甲基-4-喹诺酮类化合物收率很低，但是他们用重氮甲烷进行了有趣的环化反应，得到了25％–40％的4 - N-甲基氨基-3 H-吡唑-3收率。-螺环-2'-（3'-芳基-3'-三氟甲基）环氧乙烷。然而，与重氮乙烷的相关反应仅产生芳基（芳基肼基）乙腈和其他片段化产物。
• Sachs, Chemische Berichte, 1901, vol. 34, p. 503
  作者：Sachs

  DOI：——

  日期：——