2-((4-chlorophenyl)(phenylamino)methylene)-N-phenylhydrazine-1-carbothioamide | 136169-25-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((4-chlorophenyl)(phenylamino)methylene)-N-phenylhydrazine-1-carbothioamide
• CAS: 136169-25-0
• 化学式: C₂₀H₁₇ClN₄S
• 分子量: 380.901
• InChiKey: NNRIWRDUKQXYKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.45
• 氢给体数：
  3.0
• 氢受体数：
  2.0

文献信息

• Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives
  作者：M Campana、C Laborie、G Barbier、R Assan、R Milcent

  DOI：10.1016/0223-5234(91)90059-v

  日期：1991.4

  Eleven 1-(4-substituted alpha-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(alpha-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release and lysed the islet beta cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas.