9H-fluoren-9-ylmethyl N-[(2R)-1-(3-methoxy-5-oxo-2H-pyrrol-1-yl)-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]carbamate | 439905-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl N-[(2R)-1-(3-methoxy-5-oxo-2H-pyrrol-1-yl)-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]carbamate
• CAS: 439905-05-2
• 化学式: C₂₇H₃₀N₂O₆
• 分子量: 478.545
• InChiKey: OAJBJRFRJOULSY-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  94.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  9H-fluoren-9-ylmethyl N-[(2R)-1-(3-methoxy-5-oxo-2H-pyrrol-1-yl)-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]carbamate 在 盐酸 、 2,3-二巯基丁二酸 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 乙醚 、 乙腈 为溶剂， 反应 25.0h， 生成 2-Amino-N-[(R)-1-tert-butoxymethyl-2-(4-methoxy-2-oxo-2,5-dihydro-pyrrol-1-yl)-2-oxo-ethyl]-thioacetamide
  参考文献：
  名称：

  Total Synthesis and Semi-Synthetic Approaches to Analogues of Antibacterial Natural Product Althiomycin

  摘要：

  Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00802-2
• 作为产物：
  描述：

  Fmoc-O-叔丁基-D-丝氨酸 在 正丁基锂 、 TEA 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.75h， 生成 9H-fluoren-9-ylmethyl N-[(2R)-1-(3-methoxy-5-oxo-2H-pyrrol-1-yl)-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]carbamate
  参考文献：
  名称：

  Total Synthesis and Semi-Synthetic Approaches to Analogues of Antibacterial Natural Product Althiomycin

  摘要：

  Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00802-2

文献信息

• Total Synthesis and Semi-Synthetic Approaches to Analogues of Antibacterial Natural Product Althiomycin
  作者：Paola Zarantonello、Colin P Leslie、Rafael Ferritto、Wieslaw M Kazmierski

  DOI：10.1016/s0960-894x(01)00802-2

  日期：2002.2

  Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR. (C) 2002 Elsevier Science Ltd. All rights reserved.