2(R)-amino-3-cyclopropylmethylsulfanyl-propan-1-ol | 849093-82-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2(R)-amino-3-cyclopropylmethylsulfanyl-propan-1-ol
• 英文别名: R-2-Amino-3-cyclopropylmethylsulfanyl-propan-1-ol；(2R)-2-amino-3-(cyclopropylmethylsulfanyl)propan-1-ol
• CAS: 849093-82-9
• 化学式: C₇H₁₅NOS
• 分子量: 161.268
• InChiKey: VYLLJXBBRCMAEC-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2(R)-amino-3-cyclopropylmethylsulfanyl-propan-1-ol 在 4-甲基苯磺酸吡啶 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 5.5h， 生成 (2-cyclopropylmethylsulfanyl-1-trimethylsilanyloxy-methylethyl)-(2,2-difluoroethylidene)amine
  参考文献：
  名称：

  WO2006/102535

  摘要：

  公开号：
• 作为产物：
  描述：

  (R)-2-amino-3-cyclopropyl-methylsulfanylpropionic acid 在 lithium aluminium tetrahydride 作用下， 反应 16.0h， 生成 2(R)-amino-3-cyclopropylmethylsulfanyl-propan-1-ol
  参考文献：
  名称：

  [EN] HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
  [FR] COMPOSES CONTENANT UN HALOALKYLE UTILISE COMME INHIBITEURS DE CYSTEINE PROTEASE

  摘要：

  公开号：

  WO2005028429A3

文献信息

• Haloalkyl containing compounds as cysteine protease inhibitors
  申请人：Link O. John

  公开号：US20050182096A1

  公开（公告）日：2005-08-18

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及抑制半胱氨酸蛋白酶的化合物，特别是cathepsins B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物和制备它们的过程。
• Haloalkyl Containing Compounds as Cysteine Protease Inhibitors
  申请人：Setti Eduardo L.

  公开号：US20090023781A1

  公开（公告）日：2009-01-22

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是cathepsins B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的制药组合物和制备它们的过程。
• Processes and Intermediates Preparing Cysteine Protease Inhibitors
  申请人：Li Jiayao

  公开号：US20080114175A1

  公开（公告）日：2008-05-15

  The present invention is directed to a process for preparing certain cysteine protease inhibitors.

  本发明涉及一种制备某些半胱氨酸蛋白酶抑制剂的过程。
• Sulfonyl Containing Compounds as Cysteine Protease Inhibitors
  申请人：Mossman Craig J.

  公开号：US20080287446A1

  公开（公告）日：2008-11-20

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及抑制半胱氨酸蛋白酶的化合物，特别是猫蛋白酶B、K、L、F和S，因此在治疗由这些蛋白酶介导的疾病方面非常有用。本发明涉及包含这些化合物的制药组合物和制备它们的方法。
• Processes and intermediates preparing cysteine protease inhibitors
  申请人：ViroBay, Inc.

  公开号：US07737300B2

  公开（公告）日：2010-06-15

  The present invention is directed to a process for preparing certain cysteine protease inhibitors.

  本发明涉及一种制备特定半胱氨酸蛋白酶抑制剂的过程。