8R-(4-chlorophenyl)-4-{[(3S,4R)-4-(2-fluoro-4-methoxyphenyl)-1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)pyrrolidin-3-yl]carbonyl}-1,4-diazacyclooctane-1-carboxylic acid methyl ester | 1207512-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 8R-(4-chlorophenyl)-4-{[(3S,4R)-4-(2-fluoro-4-methoxyphenyl)-1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)pyrrolidin-3-yl]carbonyl}-1,4-diazacyclooctane-1-carboxylic acid methyl ester
• 英文别名: methyl 8R-(4-chlorophenyl)-4-{[(3S,4R)-4-(2-fluoro-4-methoxyphenyl)-1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)pyrrolidin-3-yl]carbonyl}-1,4-diazocane-1-carboxylate；Methyl-8R-(4-chlorophenyl)-4-{[(3S,4R)-4-(2-fluoro-4-methoxyphenyl)-1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)pyrrolidin-3-yl]carbonyl}-1,4-diazocan-1-carboxylat；methyl (8R)-8-(4-chlorophenyl)-4-[(3S,4R)-4-(2-fluoro-4-methoxyphenyl)-1-(1-methyl-6-oxopyridazin-3-yl)pyrrolidine-3-carbonyl]-1,4-diazocane-1-carboxylate
• CAS: 1207512-20-6
• 化学式: C₃₁H₃₅ClFN₅O₅
• 分子量: 612.101
• InChiKey: WIVTVXZUYRAGCK-ZWEKWIFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  43
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  95
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS<br/>[FR] COMPOSÉS DIAZÉPINES ET DIAZOCANES EN TANT QU'AGONISTES DE MC4
  申请人：PFIZER LTD

  公开号：WO2010015972A1

  公开（公告）日：2010-02-11

  The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, L and n are as defined in the specification. These compounds are useful as MC4 agonists.

  本发明涉及式(I)的化合物，其中R1、R2、R3、R4、L和n如规范中所定义。这些化合物可用作MC4激动剂。
• Diazepine and Diazocane Compounds As MC4 Agonists
  申请人：Andrews Mark David

  公开号：US20110136814A1

  公开（公告）日：2011-06-09

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , L and n are as defined in the specification. These compounds are useful as MC4 agonists.

  本发明涉及式（I）化合物，其中R1、R2、R3、R4、L和n如说明书中所定义。这些化合物可用作MC4激动剂。
• DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS
  申请人：Pfizer Limited

  公开号：EP2326638A1

  公开（公告）日：2011-06-01
• US8592403B2
  申请人：——

  公开号：US8592403B2

  公开（公告）日：2013-11-26