2-(4-hydroxystyryl)benzothiazole | 137449-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(4-hydroxystyryl)benzothiazole
• 英文别名: 4-(2-benzothiazol-2-yl-vinyl)-phenol；4-((1E)-2-benzothiazol-2-ylvinyl)phenol；4-[(E)-2-(1,3-benzothiazol-2-yl)ethenyl]phenol
• CAS: 137449-43-5
• 化学式: C₁₅H₁₁NOS
• 分子量: 253.324
• InChiKey: WJUPCLKTBZSLIH-JXMROGBWSA-N

物化性质

• 沸点：
  459.4±48.0 °C(Predicted)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-hydroxystyryl)benzothiazole 、 乙酸酐 以 吡啶 、 乙醚 为溶剂， 反应 5.0h， 以87%的产率得到4-(2-苯并噻唑基乙烯基)苯基乙酸酯
  参考文献：
  名称：

  Preparation and evaluation of fatty acid esters of fluorescent p-substituted phenols as substrates for measurement of lipase activity.

  摘要：

  制备了几种荧光对位取代苯酚（1a、2a、3a和4a）的脂肪酸酯。研究了它们的吸收和荧光光谱特性，以及它们作为脂肪酶活性测量底物的实用性。其中，长烷基链酯被发现适合作为荧光底物，因为它们的发射波长与相应苯酚的发射波长差异较大。特别是，4-（2-苯并噻唑基）苯基肉豆蔻酸酯（3e）、4-（2-苯并噻唑基乙烯基）苯基月桂酸酯（4d）和4-（2-苯并噻唑基乙烯基）苯基肉豆蔻酸酯（4e）被证实很容易被猪胰脂肪酶水解。

  DOI：

  10.1248/cpb.35.3029
• 作为产物：
  描述：

  2-甲基苯并噻唑 在 氢碘酸 、 乙酸酐 、 溶剂黄146 作用下， 生成 2-(4-hydroxystyryl)benzothiazole
  参考文献：
  名称：

  Notes - Methoxy-and-Hydroxy-styryl Heterocycles

  摘要：

  DOI：

  10.1021/jo01111a614

文献信息

• Detecting targets using mass tags and mass spectrometry
  申请人：Ventana Medical Systems, Inc.

  公开号：US10883999B2

  公开（公告）日：2021-01-05

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.

  本文所公开的具体实施方案涉及使用一种或多种不同的质量标记，通过直接或间接的酶催化转化特异性地沉积在靶标上，从而提供一种识别组织样本中靶标的方法。质量标签可以用稳定同位素标记，以产生化学结构相同但质量不同的质量标签。通过电离质量标签产生的质量代码可使用质谱法进行检测和/或定量。该方法可用于特定样品中多个目标的多重检测。在某些实施方案中，可制备代表组织样本切片的图谱，图谱切片包括与定量数据相对应的数据，其中质量峰的大小被确定并与相应组织样本切片的靶标量相关联。
• DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY
  申请人：Ventana Medical Systems, Inc.

  公开号：EP2588144B1

  公开（公告）日：2018-05-09
• FUNCTIONALIZED LIPOSOMES FOR IMAGING MISFOLDED PROTEINS
  申请人：ALZECA BIOSCIENCES, LLC

  公开号：US20200261605A1

  公开（公告）日：2020-08-20

  Phospholipid-polymer-aromatic conjugates comprising binding ligands, liposome compositions including the phospholipid-polymer-aromatic conjugates, and binding ligands having an affinity for misfolded proteins are described. The phospholipid-polymer-aromatic conjugate may be represented by Structural Formula I: PL-AL-HP-X-BL (I). In Formula I, PL is a phospholipid, AL is an aliphatic linkage, HP is hydrophilic polymer, X is a link between the phospholipid-polymer and the binding ligand, and BL is polycyclic aromatic compound that functions as a binding ligand. The liposomal compositions may be useful for the imaging of misfolded and/or aggregated proteins.
• US9291597B2
  申请人：——

  公开号：US9291597B2

  公开（公告）日：2016-03-22
• [EN] DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY<br/>[FR] DÉTECTION DE MATIÈRES CIBLES À L'AIDE DE MARQUEURS DE MASSE ET D'UNE SPECTROMÉTRIE DE MASSE
  申请人：VENTANA MED SYST INC

  公开号：WO2012003478A2

  公开（公告）日：2012-01-05

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.