3-((2-hydroxyphenyl)imino)-N-(o-tolyl)butanamide | 1379584-12-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((2-hydroxyphenyl)imino)-N-(o-tolyl)butanamide
• CAS: 1379584-12-9
• 化学式: C₁₇H₁₈N₂O₂
• 分子量: 282.342
• InChiKey: HVCBZQJBYCAKET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.69
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2'-甲基乙酰乙酰苯胺 、 2-氨基苯酚 以 乙醇 为溶剂， 反应 4.0h， 以79.78%的产率得到3-((2-hydroxyphenyl)imino)-N-(o-tolyl)butanamide
  参考文献：
  名称：

  DNA interaction studies of d⁹ and d¹⁰ metal complexes having Schiff base and polypyridyl ligands

  摘要：

  Four mononuclear complexes of Cu(II) and Zn(II) having a Schiff-base ligand and 1,10-phenanthroline/2,2'-bipyridine have been synthesized and characterized. From electronic spectral and magnetic susceptibility data, octahedral geometry has been proposed for the complexes. DNA-binding behaviors of these complexes are studied by absorption titration, electrochemical, and viscosity methods. The results indicate that the complexes bind to calf thymus DNA in an intercalative mode. The gel electrophoresis results reveal that 1 cleaves pBR322 DNA effectively. The ligand and its complexes have been screened for their antimicrobial activities against a few microorganisms. The data exhibit that they are better antimicrobial agents than the ligand.

  DOI：

  10.1080/00958972.2012.690037