(4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene | 39780-02-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene
• 英文别名: (4aS)-7-Methoxy-2t-methyl-2c-hydroxymethyl-1t-aethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthren；3-methoxy-16,17-secoestra-1,3,5(10)-trien-17-ol；d-1β-Ethyl-2β-methyl-2α-hydroxymethyl-7-methoxy-1,2,3,4,4aα,9,10,10aβ-octahydro-phenanthren；[(1S,2S,4aS,10aR)-1-ethyl-7-methoxy-2-methyl-3,4,4a,9,10,10a-hexahydro-1H-phenanthren-2-yl]methanol
• CAS: 39780-02-4
• 化学式: C₁₉H₂₈O₂
• 分子量: 288.43
• InChiKey: MJKNBAWIDKDEFQ-AKHDSKFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene 在 氨 、 lithium 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 3-methoxy-16,17-secoestra-2,5(10)-dien-17-ol
  参考文献：
  名称：

  16,17-Seco-delta 4,9(10) and -delta 4,9(10),11 steroids

  摘要：

  这些化合物及其14.beta.-异构体可用作抗雄激素药物，并提供了它们的制备方法。

  公开号：

  US03969412A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 铂 作用下， 生成 (4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene
  参考文献：
  名称：

  Can the human intervertebral disc be compared to a diarthrodial joint?

  摘要：

  The joint between human vertebral bodies is traditionally classified as a symphysis, a major cartilaginous synarthrosis. However, it has been suggested by some authors to compare the intervertebral disc (IVD) to a diarthrodial joint. The bases of this comparison are reviewed and discussed. In his description of 1895, Luschka saw the IVD as a diarthrodial joint containing articular cartilages and synovium in the annulus fibrosus. Subsequently, histologic and ultrastructural investigations into the cells and extracellular matrix of the nucleus pulposus (NP) supported the same hypothesis. More recently, the appearances of the IVD in magnetic resonance imaging (MRI) and discography, as well as clinical considerations were interpreted in the same way to simplify understanding of IVD pathology. However, a number of objections involving general, morphological, embryological, biochemical, histologic, radiological and clinical considerations demonstrate the limitations of this hypothesis. The general structural and mechanical principles of joint classification are mentioned to highlight the basic differences between the IVD and a synovial joint. An overview of the development of these joints, and a review of the literature dealing with ultrastructural aspects of the NP, with histopathological studies of the IVD, and with the normal appearance of the IVD on MRI and its age-related changes has led us to refute the hypothesis of this analogy. The IVD cannot be compared to a synovial joint, explaining why most of its pathologic features are quite different from those of a joint of the appendicular skeleton.

  DOI：

  10.1007/s00276-000-0101-8

文献信息

• Doisynolsäure-Derivate mit hydroaromatischem Ring A
  作者：O. Schindler

  DOI：10.1002/hlca.19600430318

  日期：——

  Durch Methylierung mit Dimethylsulfat und Alkali wurde Doisynolsäure (V) in die Methoxysäure VI übergeführt; daneben bildete sich auch deren Methylester III. Die aus VI bei der Reduktion mit Lithium in flüssigem Ammoniak erhaltenen Säuren lieferten bei der sauren Hydrolyse das αβ-ungesättigte Keton IX. Als Nebenprodukt entstanden bei dieser Reduktion neutrale Anteile, in denen die Carboxylgruppe reduziert

  通过用硫酸二甲酯和碱进行甲基化，将二异炔酸（V）转化为甲氧基酸VI；另外，还形成了它们的甲酯III。由VI通过在液态氨中用锂还原而获得的酸在酸性水解中得到αβ-不饱和酮IX。作为这种还原反应的副产物，形成了中性部分，其中的羧基必须被还原，因为它们在酸水解和CrO 3氧化后可以转化为IX。
• US3969412A
  申请人：——

  公开号：US3969412A

  公开（公告）日：1976-07-13