3,3-dimethyl-1(3H)-phenyliminobenzo[c]thiophene | 1087268-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-dimethyl-1(3H)-phenyliminobenzo[c]thiophene
• 英文别名: 3,3-dimethyl-N-phenyl-2-benzothiophen-1-imine
• CAS: 1087268-38-9
• 化学式: C₁₆H₁₅NS
• 分子量: 253.368
• InChiKey: KDWRCPDDLDHQSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(1-methylethenyl)-N-phenylthiobenzamide 在 氢碘酸 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以79%的产率得到3,3-dimethyl-1(3H)-phenyliminobenzo[c]thiophene
  参考文献：
  名称：

  Synthesis of 1(3H)-Iminobenzo[c]thiophene Derivatives by Hydriodic Acid-mediated Cyclization of 2-(Vinyl)thiobenzamide Derivatives

  摘要：

  Secondary 2-(vinyl)thiobenzamide derivatives, easily prepared by reacting 2-lithiostyrene derivatives with various isothiocyanates, undergo intramolecular cyclization on treatment with concentrated hydriodic acid to produce 1(3H)-iminobenzo[c]thiophene derivatives in fair-to-good yields. Some of them have been hydrolyzed under acidic conditions to afford benzo[c]thiophen-1(3H)-one derivatives in good yields.

  DOI：

  10.3987/com-08-11425

文献信息

• Synthesis of 1(3H)-Iminobenzo[c]thiophene Derivatives by Hydriodic Acid-mediated Cyclization of 2-(Vinyl)thiobenzamide Derivatives
  作者：Kazuhiro Kobayashi、Seiki Fujita、Hisatoshi Konishi

  DOI：10.3987/com-08-11425

  日期：——

  Secondary 2-(vinyl)thiobenzamide derivatives, easily prepared by reacting 2-lithiostyrene derivatives with various isothiocyanates, undergo intramolecular cyclization on treatment with concentrated hydriodic acid to produce 1(3H)-iminobenzo[c]thiophene derivatives in fair-to-good yields. Some of them have been hydrolyzed under acidic conditions to afford benzo[c]thiophen-1(3H)-one derivatives in good yields.