2,4-dideoxy-4-hydroxyphosphinyl-D-erythro-pentofuranose | 140422-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 金属杂环化合物
• 英文名称: 2,4-dideoxy-4-hydroxyphosphinyl-D-erythro-pentofuranose
• 英文别名: 2,4-Dideoxy-4-hydroxyphosphonoyl-α/β-D-erythro-pentofuranose；methyl 2,4-dideoxy-4-dimethoxyphosphonoyl-β-D-erythro-pentopyranoside；(4S,5R)-1-hydroxy-5-(hydroxymethyl)-1-oxo-1lambda5-phospholane-2,4-diol；(4S,5R)-1-hydroxy-5-(hydroxymethyl)-1-oxo-1λ5-phospholane-2,4-diol
• CAS: 140422-40-8；140629-89-6；140629-90-9；140629-91-0
• 化学式: C₅H₁₁O₅P
• 分子量: 182.113
• InChiKey: SAVQDRNIKZAFEV-PYHARJCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-dideoxy-4-hydroxyphosphinyl-D-erythro-pentofuranose 在 吡啶 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 24.0h， 生成 1,3,5-tri-O-acetyl-2,4-dideoxy-4-<(S)-methoxyphosphinyl>-β-D-erythro-pentofuranose
  参考文献：
  名称：

  Hanaya, Tadashi; Noguchi, Ayashi; Armour, Margaret-Ann, Journal of the Chemical Society. Perkin transactions I, 1992, # 2, p. 295 - 301

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 2,4-dideoxy-4-dimethoxyphosphinyl-D-erythro-pentopyranoside 生成 2,4-dideoxy-4-hydroxyphosphinyl-D-erythro-pentofuranose
  参考文献：
  名称：

  An efficient synthesis of 2,4-dideoxy-4-hydroxyphosphinyl-d-erythro-pentofuranose

  摘要：

  DOI：

  10.1016/0008-6215(91)80173-k

文献信息

• Improved Syntheses of D-Ribo- and 2-Deoxy-D-ribofuranose Phospho Sugars from Methyl b-D-Ribopyranoside
  作者：Tadashi Hanaya、Yuko Koga、Heizan Kawamoto、Hiroshi Yamamoto

  DOI：10.3987/com-07-s(u)34

  日期：——

  Methyl 4-deoxy-4-dimethoxyphosphinoyl-2,3-O-isopropylidene-beta-D-ribopyranoside (12a) and methyl 2,4-dideoxy-4-dimethoxyphosphinoyl-beta-D-erythro-pentopyranoside (20) were efficiently prepared respectively from methyl 2,3-O-isopropylidene-beta-D-ribopyranoside (7a) and its 3,4-O-isopropylidene isomer (7b) in appreciably improved total yields compared with those via previously reported routes. Compounds (12a, 20) were led to D-ribofuranose and 2-deoxy-D-ribofuranose phospho sugars (4, 5).
• An efficient synthesis of 2,4-dideoxy-4-hydroxyphosphinyl-d-erythro-pentofuranose
  作者：Tadashi Hanaya、Ayashi Noguchi、Hiroshi Yamamoto

  DOI：10.1016/0008-6215(91)80173-k

  日期：1991.1
• HANAYA, TADASHI;NOGUCHI, AYASHI;YAMAMOTO, HIROSHI, CARBOHYDR. RES., 209,(1991) C9-C12
  作者：HANAYA, TADASHI、NOGUCHI, AYASHI、YAMAMOTO, HIROSHI

  DOI：——

  日期：——
• Hanaya, Tadashi; Noguchi, Ayashi; Armour, Margaret-Ann, Journal of the Chemical Society. Perkin transactions I, 1992, # 2, p. 295 - 301
  作者：Hanaya, Tadashi、Noguchi, Ayashi、Armour, Margaret-Ann、Hogg, Alan M.、Yamamoto, Hiroshi

  DOI：——

  日期：——