(1R,4S,4'E,5'S,6R,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (1R,4S,4'E,5'S,6R,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• 化学式: C₃₇H₅₃NO₈
• 分子量: 639.8
• InChiKey: YZBLFMPOMVTDJY-BFPKLJSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  46
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• STABLE VETERINARY COMPOSITION COMPRISING MOXIDECTIN AND IMIDACLOPRID
  申请人：KRKA, d.d., Novo mesto

  公开号：EP3815677A1

  公开（公告）日：2021-05-05

  The invention relates to a stabilized veterinary composition comprising Moxidectin in combination with Imidacloprid and an amine base for cutaneous topical application (spot-on), to the use of an amine base for stabilizing Moxidectin, and to the use of an amine base for producing a veterinary composition with improved Moxidectin stability.

  本发明涉及一种稳定的兽用组合物，该组合物包含莫西菌素与吡虫啉以及一种用于皮肤局部施用（点涂）的胺基，本发明还涉及使用胺基来稳定莫西菌素，以及使用胺基来生产具有更高莫西菌素稳定性的兽用组合物。
• Method for the protection of trees
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US10058098B2

  公开（公告）日：2018-08-28

  The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone.

  本发明提供了一种预防/处理树皮甲虫和/或木材蛀虫侵袭树木的方法，包括用一种含有大环内酯的组合物处理树木。
• Pet care cleansing composition
  申请人：BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.

  公开号：US10722448B2

  公开（公告）日：2020-07-28

  A method of treating the skin or hair on a dog containing an effective amount of an ectoparasiticide previously applied to the skin or hair, comprising applying a quantity of a cleansing composition directly to the skin or hair, wherein the treatment does not result in reducing the efficacy of the ectoparasiticide against adult fleas (C. felis) or adult ticks (R. sanguineus) below 90% efficacy for at least a month after application of the ectoparasiticide; wherein the cleansing composition comprises about 1-3% glycerin; about 2-4% silicone copolyol esters, water and is essentially free of surfactant.

  一种处理狗的皮肤或毛发的方法，该方法包含将一定量的清洁组合物直接施用到狗的皮肤或毛发上，其中，在施用外寄生虫杀虫剂后的至少一个月内，该处理不会导致外寄生虫杀虫剂对成虫跳蚤（C.蚤）或成蜱（R. sanguineus）的效力低于90%；其中清洁组合物包含约1-3%的甘油；约2-4%的硅氧烷共聚醇酯和水，并且基本上不含表面活性剂。
• METHODS OF REDUCING NEMATODE DAMAGE
  申请人：Syngenta Participations AG

  公开号：EP1765079A1

  公开（公告）日：2007-03-28
• METHOD FOR THE PROTECTION OF TREES
  申请人：The Texas A&M University System

  公开号：EP1863496A2

  公开（公告）日：2007-12-12