(4S)-4-(4-cyano-2-methylsulfonylphenyl)-2,5-dioxo-N-propan-2-yl-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide | 1621272-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S)-4-(4-cyano-2-methylsulfonylphenyl)-2,5-dioxo-N-propan-2-yl-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide
• CAS: 1621272-14-7
• 化学式: C₂₆H₂₃F₃N₄O₅S
• 分子量: 560.554
• InChiKey: QBJDJBOKVXRKEZ-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  39
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  136
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160340319A1

  公开（公告）日：2016-11-24

  This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
• US9670166B2
  申请人：——

  公开号：US9670166B2

  公开（公告）日：2017-06-06