Bis(2,2'-diazidobenzyl) ether | 159428-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis(2,2'-diazidobenzyl) ether
• 英文别名: 1-Azido-2-[(2-azidophenyl)methoxymethyl]benzene
• CAS: 159428-13-4
• 化学式: C₁₄H₁₂N₆O
• 分子量: 280.289
• InChiKey: CTTDIWKORPNPQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Bis(2,2'-diazidobenzyl) ether 以 乙醚 、 苯 为溶剂， 反应 10.0h， 生成 1-Isothiocyanato-2-[(2-isothiocyanatophenyl)methoxymethyl]benzene
  参考文献：
  名称：

  A New and Efficient Preparation of Cyclic Carbodiimides from Bis(iminophosphoranes) and the System Boc2O/DMAP

  摘要：

  A one-pot synthesis of cyclic carbodiimides which involves reaction of C,C-bis(aryliminophosphoranes) connected by aliphatic bridges with Boc(2)O in the presence of DMAP is described. The method is also applicable when a heteroatom such as oxygen or nitrogen is incorporated into the tether connecting the two aromatic rings. A conformation study has been carried out on carbodiimide 23a, which posseses a central nine-membered ring, using H-1 NMR spectroscopy and semiempirical as well as molecular mechanics calculations.

  DOI：

  10.1021/jo00103a022
• 作为产物：
  描述：

  2-azidobenzyl alcohol 、 1-叠氮基-2-(氯甲基)苯 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 苯 为溶剂， 反应 6.0h， 以80%的产率得到Bis(2,2'-diazidobenzyl) ether
  参考文献：
  名称：

  A New and Efficient Preparation of Cyclic Carbodiimides from Bis(iminophosphoranes) and the System Boc2O/DMAP

  摘要：

  A one-pot synthesis of cyclic carbodiimides which involves reaction of C,C-bis(aryliminophosphoranes) connected by aliphatic bridges with Boc(2)O in the presence of DMAP is described. The method is also applicable when a heteroatom such as oxygen or nitrogen is incorporated into the tether connecting the two aromatic rings. A conformation study has been carried out on carbodiimide 23a, which posseses a central nine-membered ring, using H-1 NMR spectroscopy and semiempirical as well as molecular mechanics calculations.

  DOI：

  10.1021/jo00103a022

文献信息

• POLY(ORGANOPHOSPHAZENE) COMPOSITION FOR BIOMATERIALS
  申请人：SONG Soo-Chang

  公开号：US20130004455A1

  公开（公告）日：2013-01-03

  Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

  提供了一种用于生物材料的化学交联可用的聚（有机磷氮烷）的用途，与生理活性物质共价结合的化学交联聚（有机磷氮烷），以及其用于生物材料的用途，以及制备这些材料的过程。这种化学交联可以通过紫外辐射、交联剂、添加剂、酶、至少一种聚合物的混合等方法实现。
• An efficient preparation of macrocycles containing two tetra-coordinate phosphorus atoms
  作者：P. Molina、M. Alajarín、A. Arques、P. Sánchez-Andrada、A. Vidal、M.V. Vinader

  DOI：10.1016/s0022-328x(96)06494-7

  日期：1997.2

  The Staudinger reaction between bis(azides) and bis(phosphines) under mild conditions provides macrocyclic bis(iminophosphoranes) (at least 12-membered rings) in excellent to moderate yield. The method also allows the incorporation of a heteroatom into the chain connecting the two aromatic or heteroaromatic rings.