N-Methyl-2-hydroxy-pyridinium | 38481-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-Methyl-2-hydroxy-pyridinium
• 英文别名: 1-methyl-1H-pyridin-1-ium-2-one
• CAS: 38481-05-9
• 化学式: C₆H₈NO
• 分子量: 110.136
• InChiKey: DVVGIUUJYPYENY-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  21.5
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] 1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS<br/>[FR] DÉRIVÉS DE 1-HÉTÉROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE ET LEURS UTILISATIONS À TITRE DE MODULATEURS DE PDE9A
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009121919A1

  公开（公告）日：2009-10-08

  The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones, Formula (I) with Hc is a mono-, bi- or tricyclic heterocyclyl group, the ring members of which are carbon atoms and at least 1, preferably 1, 2 or 3, heteroatom(s), which are selected from the group of nitrogen, oxygen and sulphur, which is in the form of -S(O)r - with r being 0, 1 or 2, and - said heterocyclyl group is or comprises 1 non-aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member and - said heterocyclyl group is bound to the scaffold by said 1 non- aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member. According to one aspect of the invention the new compounds are for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease.

  该发明涉及新型1,6-二取代吡唑吡嘧啶酮，化学式（I），其中Hc是一个单环、双环或三环杂环基团，其环成员为碳原子和至少1个，优选1个、2个或3个来自氮、氧和硫的杂原子，其以-S(O)r-的形式存在，其中r为0、1或2，所述杂环基团是或包括1个非芳香、饱和或部分不饱和的单环环，其中至少包含1个杂原子作为环成员，所述杂环基团通过所述至少包含1个杂原子作为环成员的非芳香、饱和或部分不饱和的单环环与支架相结合。根据该发明的一个方面，新化合物用于制造药物，特别是用于治疗感知、注意力、学习或记忆缺陷相关疾病的药物。新化合物还用于制造治疗阿尔茨海默病的药物。
• Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof
  申请人：Petasis Nicos A.

  公开号：US20090247766A1

  公开（公告）日：2009-10-01

  The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.

  该发明涉及一种化学式为1的氮杂环化合物。还公开了一种合成该化合物的方法，以及利用该化合物治疗各种疾病和病况的用途。
• Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis
  申请人：Dudley Gregory

  公开号：US20100324324A1

  公开（公告）日：2010-12-23

  A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.

  一种苯甲基化醇的方法包括将2-苄氧基-1-甲基吡啶三氟甲磺酸盐与具有预定沸点的芳香族烃溶剂混合；向混合物中添加酸清除剂；将待苯甲基化的醇与混合物结合；通过加热至高于环境温度使醇与2-苄氧基-1-甲基吡啶三氟甲磺酸盐反应，以生成苯甲基化醇；并从混合物中分离出苯甲基化醇。
• HYDROXY-SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS
  申请人：SCHERING CORPORATION

  公开号：EP0720599B1

  公开（公告）日：1999-05-19
• NEW MATERIALS
  申请人：BIOCOMPATIBLES LIMITED

  公开号：EP0682535A1

  公开（公告）日：1995-11-22