N-(2-hydroxyethyl)pyrrolidine-1-carboxamide | 1478581-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(2-hydroxyethyl)pyrrolidine-1-carboxamide
• CAS: 1478581-05-3
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: AXWWBZDXDIIEGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
  申请人：Himmelsbach Frank

  公开号：US20050182043A1

  公开（公告）日：2005-08-18

  The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.

  本发明涉及一种治疗疾病的方法，所述疾病包括良性或恶性肿瘤、呼吸道和肺部疾病、胆道和胆囊疾病以及胃肠道疾病，通过向需要治疗的患者施用以下一般式的双环杂环基的治疗有效量：其中所述取代基如定义所述。
• BICYCLIC HETEROCYCLIC COMPOUNDS PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THE SAME
  申请人：HIMMELSBACH Frank

  公开号：US20110077246A1

  公开（公告）日：2011-03-31

  The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.

  本发明涉及治疗疾病的方法，所述疾病包括良性或恶性肿瘤、呼吸道和肺部疾病、胃肠道疾病、胆管和胆囊疾病，通过向需要治疗的患者施用下列一般式的双环杂环基的治疗有效量：其中所述取代基如本文所定义。
• 4- ( N-PHENYLAMINO ) -CHINAZOLINE/CHINOLINE ALS TYROSINKINASEINHIBITOREN
  申请人：Boehringer Ingelheim Pharma GmbH & Co.KG

  公开号：EP1492536B1

  公开（公告）日：2012-05-09
• N4-PHENYL-QUINAZOLINE-4 -AMINE DERIVATIVES AND RELATED COMPOUNDS AS ERBB TYPE I RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
  申请人：Array Biopharma Inc.

  公开号：EP1971601B1

  公开（公告）日：2009-10-21
• US6924285B2
  申请人：——

  公开号：US6924285B2

  公开（公告）日：2005-08-02