2-Phenylthio-2-imidazolin | 54255-15-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Phenylthio-2-imidazolin
• 英文别名: 2-phenylsulfanyl-4,5-dihydro-1H-imidazole；2-phenylsulfanyl-4,5-dihydro-1H-imidazole
• CAS: 54255-15-1
• 化学式: C₉H₁₀N₂S
• 分子量: 178.258
• InChiKey: UYJDOEXEYWDWKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method for treating central nervous system disorders with substituted 2-imidazoline derivatives
  申请人：Hoener Marius

  公开号：US20070197569A1

  公开（公告）日：2007-08-23

  The present invention relates to a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, X, A, and n are as defined in the specification and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms thereof.

  本发明涉及一种治疗抑郁症、焦虑障碍、双相情感障碍、注意力缺陷多动障碍（ADHD）、与压力相关的障碍、如精神分裂症等精神障碍、帕金森病等神经系统疾病、阿尔茨海默病等神经退行性疾病、癫痫、偏头痛、高血压、物质滥用和代谢性疾病，如进食障碍、糖尿病、糖尿病并发症、肥胖症、血脂异常、能量消耗和吸收障碍、体温稳态障碍和功能障碍、睡眠和昼夜节律障碍、心血管疾病的方法，包括向个体施用化合物I的治疗有效量，其中R、X、A和n如规范中所定义，以及其药用活性盐、外消旋混合物、对映体、光学异构体和互变异构体形式。