1-[2-tert-butyl-4-(3-fluorophenyl)-1-methyl-1H-imidazol-5-yl]-3-[5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl]urea | 1355346-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-[2-tert-butyl-4-(3-fluorophenyl)-1-methyl-1H-imidazol-5-yl]-3-[5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl]urea
• 英文别名: 1-[2-Tert-butyl-5-(3-fluorophenyl)-3-methylimidazol-4-yl]-3-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]urea
• CAS: 1355346-78-9
• 化学式: C₃₁H₃₁FN₆O₄
• 分子量: 570.623
• InChiKey: OPDOEHJRGLIPJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NITROGEN-CONTAINING AROMATIC HETEROCYCLIC DERIVATIVE
  申请人：Furuta Takayuki

  公开号：US20130225581A1

  公开（公告）日：2013-08-29

  The present invention provides a nitrogen-containing aromatic heterocyclic derivative represented by formula (I): [wherein W represents CR 3 (wherein R 3 represents a hydrogen atom or the like) or the like, R 4 represents a hydrogen atom or the like, R 5 represents a hydrogen atom or the like, R 9 represents substituted imidazolyl, R 12 and R 13 may be the same or different, each represent a hydrogen atom or the like, R 22 and R 23 may be the same or different, each represent a hydrogen atom or the like, R 24 represents a hydrogen atom or the like, Y represents C—R 25 (wherein R 25 represents a hydrogen atom or the like) or the like] or a pharmaceutically acceptable salt thereof and a FGFR inhibitor comprising, as an active ingredient, the nitrogen-containing aromatic heterocyclic derivative or the pharmaceutically acceptable salt thereof, or the like.

  本发明提供一种由式(I)表示的含氮芳杂环衍生物：[其中W代表CR3（其中R3代表氢原子或类似物）或类似物，R4代表氢原子或类似物，R5代表氢原子或类似物，R9代表取代咪唑基，R12和R13可以相同也可以不同，每个代表氢原子或类似物，R22和R23可以相同也可以不同，每个代表氢原子或类似物，R24代表氢原子或类似物，Y代表C-R25（其中R25代表氢原子或类似物）或类似物]或其药学上可接受的盐，以及一种包含上述含氮芳杂环衍生物或其药学上可接受的盐作为活性成分的FGFR抑制剂，或类似物。
• NITROGENATED AROMATIC HETEROCYCLIC RING DERIVATIVE
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2594566A1

  公开（公告）日：2013-05-22

  The present invention provides a nitrogen-containing aromatic heterocyclic derivative represented by formula (I): [wherein W represents CR3 (wherein R3 represents a hydrogen atom or the like) or the like, R4 represents a hydrogen atom or the like, R5 represents a hydrogen atom or the like, R9 represents substituted imidazolyl, R12 and R13 may be the same or different, each represent a hydrogen atom or the like, R22 and R23 may be the same or different, each represent a hydrogen atom or the like, R24 represents a hydrogen atom or the like, Y represents C-R25 (wherein R25 represents a hydrogen atom or the like) or the like] or a pharmaceutically acceptable salt thereof and a FGFR inhibitor comprising, as an active ingredient, the nitrogen-containing aromatic heterocyclic derivative or the pharmaceutically acceptable salt thereof, or the like.

  本发明提供了一种由式（I）表示的含氮芳香杂环衍生物： [其中W代表CR3(其中R3代表氢原子或类似物)或类似物，R4代表氢原子或类似物，R5代表氢原子或类似物，R9代表取代的咪唑基，R12和R13可以相同或不同，各自代表氢原子或类似物，R22和R23可以相同或不同，各自代表氢原子或类似物、R24代表氢原子或类似物，Y代表C-R25（其中R25代表氢原子或类似物）或类似物]或其药学上可接受的盐，以及包含作为活性成分的含氮芳香杂环衍生物或其药学上可接受的盐或类似物的FGFR抑制剂。