tert-butyl [1-(4-{[3-nitro-6-(phenylthio)pyridin-2-yl]amino}phenyl)cyclobutyl]carbamate | 1416775-56-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: tert-butyl [1-(4-{[3-nitro-6-(phenylthio)pyridin-2-yl]amino}phenyl)cyclobutyl]carbamate
• 英文别名: tert-butyl N-[1-[4-[(3-nitro-6-phenylsulfanylpyridin-2-yl)amino]phenyl]cyclobutyl]carbamate
• CAS: 1416775-56-8
• 化学式: C₂₆H₂₈N₄O₄S
• 分子量: 492.599
• InChiKey: JNLJYXVGBAOQOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted Imidazopyridinyl-Aminopyridine Compounds
  申请人：Ashwell Mark A.

  公开号：US20120329791A1

  公开（公告）日：2012-12-27

  The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代咪唑吡啶基-氨基吡啶化合物及其合成方法。本发明还涉及含有取代咪唑吡啶基-氨基吡啶化合物的药物组合物，以及通过向需要的受试者投予这些化合物和药物组合物来治疗细胞增殖障碍，如癌症的方法。
• SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS
  申请人：ArQule, Inc.

  公开号：EP2723741B1

  公开（公告）日：2016-04-27
• US8962619B2
  申请人：——

  公开号：US8962619B2

  公开（公告）日：2015-02-24
• [EN] SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS D'IMIDAZOPYRIDINYLE-AMINOPYRIDINE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2012177844A2

  公开（公告）日：2012-12-27

  The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl- aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.