4-chlorobenzyl 4-[4-(3-amino-1H-indazol-6-ylcarbamoyl)thiazol-2-yl]piperidine-1-carboxylate | 1143507-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chlorobenzyl 4-[4-(3-amino-1H-indazol-6-ylcarbamoyl)thiazol-2-yl]piperidine-1-carboxylate
• 英文别名: (4-chlorophenyl)methyl 4-[4-[(3-amino-1H-indazol-6-yl)carbamoyl]-1,3-thiazol-2-yl]piperidine-1-carboxylate
• CAS: 1143507-72-5
• 化学式: C₂₄H₂₃ClN₆O₃S
• 分子量: 511.004
• InChiKey: ARHNZPZTUVWIEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  155
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• THIAZOLE DERIVATIVES
  申请人：Schiemann Kai

  公开号：US20100240676A1

  公开（公告）日：2010-09-23

  Compounds of the formula (I), in which R 1 , R 2 , R 3 , R 4 , K, G, E and W

  化学式为（I）的化合物，其中R1，R2，R3，R4，K，G，E和W。
• THIAZOLDERIVATE ZUR BEHANDLUNG VON KREBS
  申请人：Merck Patent GmbH

  公开号：EP2209777B1

  公开（公告）日：2015-07-29
• COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS
  申请人：BROWN Dennis M.

  公开号：US20160067241A1

  公开（公告）日：2016-03-10

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to naphthalimides such as amonafide or analogs, derivatives, or prodrugs thereof.
• US8557824B2
  申请人：——

  公开号：US8557824B2

  公开（公告）日：2013-10-15
• [EN] COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'AMÉLIORER LE BÉNÉFICE THÉRAPEUTIQUE DES COMPOSÉS CHIMIQUES ADMINISTRÉS DE MANIÈRE SUBOPTIMALE COMPRENANT DES NAPHTALIMIDES SUBSTITUÉS TELS QUE L'AMONAFIDE POUR LE TRAITEMENT DES MALADIES IMMUNOLOGIQUES, MÉTABOLIQUES, INFECTIEUSES ET INFECTIEUSES OU HYPERPROLIFÉRATIVES ET NÉOPLASTIQUES.
  申请人：BROWN DENNIS M

  公开号：WO2014179528A2

  公开（公告）日：2014-11-06

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to naphthalimides such as amonafide or analogs, derivatives, or prodrugs thereof.