4-肼基-N-甲基苯基乙烷磺酰胺 | 121679-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-肼基-N-甲基苯基乙烷磺酰胺
• 中文别名: 4-肼基-N-甲苯乙烷磺酰胺盐酸盐；4-肼基-N-甲基苯乙烷磺酰胺
• 英文名称: 4-hydrazino-N-methyl-benzenethanesulphonamide
• 英文别名: 2-(4-Hydrazinylphenyl)-N-methylethanesulfonamide
• CAS: 121679-30-9
• 化学式: C₉H₁₅N₃O₂S
• 分子量: 229.303
• InChiKey: CCZBHURGHJQGCB-UHFFFAOYSA-N

物化性质

• 密度：
  1.308

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.6
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  4-肼基-N-甲基苯基乙烷磺酰胺 生成 2-[3-[2-(ethylamino)ethyl]-1H-indol-5-yl]-N-methylethanesulfonamide
  参考文献：
  名称：

  OXFORD, A. W.;EVANS, B.;DOWLE, M. D.;COATES, I. H.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-nitro-phenyl)ethanesulfonic acid methylamide 生成 4-肼基-N-甲基苯基乙烷磺酰胺
  参考文献：
  名称：

  OXFORD, A. W.;EVANS, B.;DOWLE, M. D.;COATES, I. H.

  摘要：

  DOI：

文献信息

• Indole derivatives
  申请人：Glaxo Group Limited

  公开号：US04997841A1

  公开（公告）日：1991-03-05

  Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents H or C.sub.1-6 alkyl; R.sub.2 represents H or C.sub.1-6 alkyl; R.sub.3 represents H; R.sub.4 represents H or C.sub.1-3 alkyl; and pharmaceutically acceptable salts and solvates (for example hydrates thereof. The compounds are indicated as useful for the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.

  公式（I）的化合物已被披露，其中R.sub.1代表H或C.sub.1-6烷基；R.sub.2代表H或C.sub.1-6烷基；R.sub.3代表H；R.sub.4代表H或C.sub.1-3烷基；以及药用盐和溶剂化物（例如其水合物）。这些化合物被指示用于治疗偏头痛、集束头痛、慢性周期性半边头痛和与血管疾病相关的头痛。还披露了其制备的过程和中间体，以及含有它们的药物组合物。
• [EN] A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN<br/>[FR] PROCÉDÉ DE SYNTHÈSE DU NARATRIPTAN
  申请人：CIPLA LTD

  公开号：WO2011021000A2

  公开（公告）日：2011-02-24

  The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.

  本发明涉及一种制备纳拉曲坦或其盐的方法，该方法包括：(a)将式(3)的化合物与式HCCR的化合物反应，其中Z为保护基，Y为离去基，R为三烷基硅基，三烷基锡基或锌(II)卤化物，得到式(4)的化合物；(b)将式(4)的化合物转化为式(5)的化合物，其中Z'为氢或苄基；(c)将式(5)的化合物转化为纳拉曲坦；以及(d)可选地将纳拉曲坦转化为其盐。本发明还提供了新的化合物(3)和(4)以及其制备方法。
• Process for the synthesis of naratriptan
  申请人：Rao Dharmaraj Ramachandra

  公开号：US20120220778A1

  公开（公告）日：2012-08-30

  The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z′ is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.

  本发明涉及一种制备纳拉替普坦或其盐的方法，该方法包括：(a)将式（3）的化合物与式HCCR的化合物反应，其中Z是保护基，Y是离去基团，R是三烷基硅基，三烷基锡基或锌(II)卤化物，以获得式（4）的化合物；(b)将式（4）的化合物转化为式（5）的化合物，其中Z'是氢或苄基；(c)将式（5）的化合物转化为纳拉替普坦；以及(d)可选地将纳拉替普坦转化为其盐。本发明还提供了新型化合物（3）和（4）以及其制备方法。
• A novel synthetic approach towards pyrazole-4-carboxamides using N-(3-(dimethylamino)-2-formylacryloyl)formamide
  作者：Madhukar N. Jachak、Maruti G. Ghagare、Dilip R. Birari、Ramhari V. Rote、Muddassar A. Kazi、Sanjay M. Jachak、Raghunath B. Toche

  DOI：10.1007/s00706-010-0290-8

  日期：2010.5

  A novel synthesis of pyrazole-4-carboxamides is reported. The reaction of N-(3-(dimethylamino)-2-formylacryloyl) formamide, an intermediate obtained by Vilsmeier-Haack formylation of acetonitrile, with hydrazine hydrate or monosubstituted hydrazines provides such compounds in good yields. This method has advantages over other methods for construction of such ring systems previously described in the literature.
• A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN
  申请人：Cipla Limited

  公开号：EP2467373B1

  公开（公告）日：2013-10-02