6-(diisopropyloamino)-hexanol | 74509-53-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-(diisopropyloamino)-hexanol
• 英文别名: 6-(N,N-di-isopropylamino)hexanol；6-[Di(propan-2-yl)amino]hexan-1-ol
• CAS: 74509-53-8
• 化学式: C₁₂H₂₇NO
• 分子量: 201.352
• InChiKey: RLBSPJMNBCEVOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(diisopropyloamino)-hexanol 在 氯化亚砜 作用下， 生成 6-chloro-N,N-di(propan-2-yl)hexan-1-amine
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004
• 作为产物：
  描述：

  甲基脂肪酰氯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 3.0h， 生成 6-(diisopropyloamino)-hexanol
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004

文献信息

• PROCESS FOR PREPARING (METH)ACRYLIC ACID
  申请人：Vogel Bernd

  公开号：US20100029979A1

  公开（公告）日：2010-02-04

  The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.

  本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂的存在下将环状酯转化为（甲基）丙烯酸。制备的（甲基）丙烯酸可以特别地转化为（甲基）丙烯酸酯。
• PROCESS FOR PREPARING TETRAMETHYL GLYCOLIDE
  申请人：Vogel Bernd

  公开号：US20100010276A1

  公开（公告）日：2010-01-14

  The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.

  本发明涉及一种制备四甲基乙二酰乙酯的方法，包括将含有至少50%重量的2-羟基异丁酸和/或四甲基乙二酰乙酯的组合物加热至至少100℃的温度。
• Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs
  申请人：SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

  公开号：EP0289262A2

  公开（公告）日：1988-11-02

  Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti-­inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.

  本发明公开了酸性非甾体抗炎药（NSAIDs）的季铵烷基酯和硫代酯。这些酯类和硫代酯类具有母体非甾体抗炎药的抗炎特性，但胃肠道刺激性大大降低，与母体非甾体抗炎药相比，能更有效地将治疗活性和毒副作用分开。
• Recombinant cell producing 2-hydroxyisobutyric acid
  申请人：Reinecke Liv

  公开号：US10174349B2

  公开（公告）日：2019-01-08

  The invention relates to a cell which has been genetically modified so as to be capable of producing more 2-hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A as intermediate and 3-hydroxybutyryl-coenzyme A as precursor.

  本发明涉及一种经过基因修饰的细胞，与野生型相比，该细胞能够产生更多的 2-羟基异丁酸或含有 2-羟基异丁酸单体单元的更多的聚羟基烷酸酯，其特征在于 2-羟基异丁酸或含有 2-羟基异丁酸单体单元的聚羟基烷酸酯是通过乙酰乙酰辅酶 A 作为中间体和 3-羟基丁酰辅酶 A 作为前体产生的。
• Gene delivery carrier
  申请人：Massachusetts Institute of Technology

  公开号：US11041069B2

  公开（公告）日：2021-06-22

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

  本文公开了制备和利用聚（β-氨基酯）（PBAE）聚合物的方法、组合物、试剂、系统和试剂盒，这些聚合物是通过本文公开的二丙烯酸酯和胺的迈克尔加成反应合成的。不同的实施例利用内酯和内酯衍生物生成二丙烯酸酯化合物。事实证明，PBAE 聚合物是一种有效的可生物降解载体，可用于传递有机分子、无机分子、核酸、蛋白质、肽、多核苷酸、靶向剂、同位素标记的化合物、疫苗或免疫制剂等制剂。