2-(prop-2-yn-1-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione | 39488-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(prop-2-yn-1-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
• 英文别名: 2-prop-2-ynyl-3a,4,7,7a-tetrahydro-4,7-methano-isoindole-1,3-dione；4-(Prop-2-yn-1-yl)-4-azatricyclo[5.2.1.0,6]dec-8-ene-3,5-dione；4-prop-2-ynyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• CAS: 39488-03-4
• 化学式: C₁₂H₁₁NO₂
• 分子量: 201.225
• InChiKey: VVYAQRKTLMSPMF-UHFFFAOYSA-N

物化性质

• 沸点：
  388.4±42.0 °C(Predicted)
• 密度：
  1.301±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(prop-2-yn-1-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 在 palladium diacetate 、 copper(l) iodide copper bromide 、 二异丙胺 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Highly regioselective palladium/copper-catalysed cross-coupling reactions of terminal alkynes and allenes

  摘要：

  The Pd/Cu-catalysed cross-coupling reaction of heterocyclic terminal alkynes and allene/allenyl heterocycles affords novel trisubstituted en-ynes in good yield. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.160
• 作为产物：
  描述：

  炔丙胺 、 (1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以92%的产率得到2-(prop-2-yn-1-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
  参考文献：
  名称：

  Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

  摘要：

  胶束纳米颗粒被设计为对基质金属蛋白酶(MMPs)和活性氧化物(ROS)具有响应性，这两者在炎症性疾病的病理生理过程中均上调。

  DOI：

  10.1039/c5cc09164k

文献信息

• Copolymer formulation for directed self-assembly, methods of manufacture thereof and articles comprising the same
  申请人：Dow Global Technologies LLC

  公开号：US10351727B2

  公开（公告）日：2019-07-16

  Disclosed herein is a pattern forming method comprising disposing upon a substrate a composition comprising a block copolymer; where the block copolymer comprises a first polymer and a second polymer; where the first polymer and the second polymer of the block copolymer are different from each other and the block copolymer forms a phase separated structure; an additive polymer; where the additive polymer comprises a bottlebrush polymer; and where the bottlebrush polymer comprises a polymer that has a lower or a higher surface energy than the block copolymer; and a solvent; and annealing the composition to facilitate domain separation between the first polymer and the second polymer of the block copolymer to form a morphology of periodic domains formed from the first polymer and the second polymer; where a longitudinal axis of the periodic domains are parallel to the substrate.

  本文公开了一种图案形成方法，该方法包括在基底上放置一种组合物，该组合物包括嵌段共聚物；其中嵌段共聚物包括第一聚合物和第二聚合物；其中嵌段共聚物的第一聚合物和第二聚合物彼此不同，且嵌段共聚物形成相分离结构；添加剂聚合物；其中添加剂聚合物包括瓶丛聚合物；退火组合物，以促进嵌段共聚物的第一聚合物和第二聚合物之间的畴分离，从而形成由第一聚合物和第二聚合物形成的周期性畴的形态；周期性畴的纵轴平行于基底。
• COPOLYMER FORMULATION FOR DIRECTED SELF-ASSEMBLY, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME
  申请人：Dow Global Technologies LLC

  公开号：US20160251508A1

  公开（公告）日：2016-09-01

  Disclosed herein is a composition comprising a block copolymer; where the block copolymer comprises a first polymer and a second polymer; where the first polymer and the second polymer of the block copolymer are different from each other and the block copolymer forms a phase separated structure; an additive polymer; where the additive polymer comprises a bottle brush polymer; where the bottle brush polymer comprises a homopolymer that is the chemically and structurally the same as one of the polymers in the block copolymer or where the additive polymer comprises a graft copolymer that has a preferential interaction with one of the blocks of the block copolymers; and a solvent.
• US9772554B2
  申请人：——

  公开号：US9772554B2

  公开（公告）日：2017-09-26
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  公开号：US9765214B2

  公开（公告）日：2017-09-19
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  申请人：——

  公开号：US9840637B2

  公开（公告）日：2017-12-12