N-Butyl-hydroxypyrid-4-one | 104764-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-Butyl-hydroxypyrid-4-one
• 英文别名: 1-butyl-3-hydroxypyridin-4-one
• CAS: 104764-54-7
• 化学式: C₉H₁₃NO₂
• 分子量: 167.2
• InChiKey: NQEKGNZFNVRSMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Iron 3-hydroxypyrone or 3-hydroxypyridone complexes and pharmaceutical compositions containing them
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0159194A2

  公开（公告）日：1985-10-23

  Iron complexes comprising a ferric cation in combination with at least two different ligands, at least one of which is provided by a compound being: (1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or (2) a 3-hydroxyprid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is . replaced by an aliphtic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphtic hydrocarbon group substituted by one or more substituents selected from aliphatic acyl, alkoxy, aliphatic amide, aliphatic ester, halogen and hydroxy groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group; the charge on the ferric cation being neutralised by the charge on the ligands covalently bound thereto; are of value in medicine, particularly in the treatment of iron deficiency anaemia.

  铁络合物，包括一个铁阳离子与至少两个不同配体的组合，其中至少一个配体由以下化合物提供： (1) 3-羟基-4-吡喃酮或 3-羟基-4-吡喃酮，其中与环碳原子相连的一个或多个氢原子被 1 至 6 个碳原子的脂族烃基取代；或 (2) 3-羟基-2-吡啶酮或 3-羟基-4-吡啶酮，其中与氮原子相连的氢原子被.被脂族酰基、1 至 6 个碳原子的脂族烃基或 1 至 6 个碳原子的脂族烃基取代，或被一个或多个选自脂族酰基、烷氧基、脂族酰胺、脂族酯的取代基取代的脂族烃基取代、卤素和羟基基团取代的脂族烃基，或由 1 至 6 个碳原子的脂族烃基取代的脂族烃基，或由烷氧基、脂族酯、卤素或羟基基团取代的脂族烃基；铁阳离子上的电荷被与其共价结合的配体上的电荷所中和；这些物质在医学上，特别是在治疗缺铁性贫血症方面具有重要价值。
• US20140271885A1
  申请人：——

  公开号：US20140271885A1

  公开（公告）日：2014-09-18
• US5177068A
  申请人：——

  公开号：US5177068A

  公开（公告）日：1993-01-05