N³-Phenyl-p-nitro-benzamidrazon | 14359-81-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N³-Phenyl-p-nitro-benzamidrazon
• 英文别名: N-amino-4-nitro-N'-phenylbenzenecarboximidamide
• CAS: 14359-81-0
• 化学式: C₁₃H₁₂N₄O₂
• 分子量: 256.264
• InChiKey: IOTZZRJIMCUVIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.55
• 氢给体数：
  2.0
• 氢受体数：
  4.0

文献信息

• Bridgehead nitrogen heterocycles. Synthesis of [1,2,4]triazolo[1,5-a]pyridin-1-ium and pyrido[2,1-f][1,2,4]triazin-9-ium derivatives
  作者：Pedro Molina、Alberto Tárraga、María Jesús Vilaplana、Emilia Hurtado、Mercedes Lorenzo

  DOI：10.1039/p19830001395

  日期：——

  A number of derivatives of bridgehead nitrogen heterocycles from pyrylium salts and amidrazones have been prepared. 2-Methylthio-4,6-diphenylpyrylium tetrafluoroborate (13) reacts with N3-aryl substituted amidrazones to yield derivatives of [1,2,4]triazolo[1,5-a]pyridin-1-ium tetrafluoroborates [(17)–(21)]. 2-Ethoxycarbonyl-4,6-diphenylpyrylium (14) reacts with N3-aryl substituted amidrazones to give

  已经制备了许多来自吡喃鎓盐和酰胺基的桥头氮杂环衍生物。2-甲硫基-4,6-二苯基四氟硼酸吡啶鎓盐（13）与N 3-芳基取代的酰胺dra反应生成[1,2,4]三唑并[1,5 - a ]吡啶-1-四氟硼酸鎓衍生物[（17） –（21）]。2-乙氧基羰基-4,6-二苯基吡啶鎓（14）与N 3-芳基取代的dra酰胺反应，生成4-氧吡喃并[2,1- f ] [1,2,4]三嗪9-鎓衍生物[（23）– （27）]。化合物（14）在中性条件下也与未取代的dra胺反应，生成相应的吡啶鎓盐[（29）-（33）]；这些在用碱处理时被环化，得到两性离子4-氧化吡啶基[2,1- f] [1,2,4] triazin-9-ium化合物[（34）–（39）]。
• Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives
  作者：M Campana、C Laborie、G Barbier、R Assan、R Milcent

  DOI：10.1016/0223-5234(91)90059-v

  日期：1991.4

  Eleven 1-(4-substituted alpha-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(alpha-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release and lysed the islet beta cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas.
• MOLINA, P.;TARRAGA, A.;VILAPLANA, M. J.;HURTADO, E.;LORENZO, M., J. CHEM. SOC. PERKIN TRANS., 1983, N 7, 1395-1399
  作者：MOLINA, P.、TARRAGA, A.、VILAPLANA, M. J.、HURTADO, E.、LORENZO, M.

  DOI：——

  日期：——