5,5,10,10-Tetramethyl-4b,5,9b,10-tetrahydro-indeno[2,1-a]indene-3,8-disulfonic acid bis-hydroxyamide | 13937-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 5,5,10,10-Tetramethyl-4b,5,9b,10-tetrahydro-indeno[2,1-a]indene-3,8-disulfonic acid bis-hydroxyamide
• 英文别名: 3-N,8-N-dihydroxy-5,5,10,10-tetramethyl-4b,9b-dihydroindeno[2,1-a]indene-3,8-disulfonamide
• CAS: 13937-97-8
• 化学式: C₂₀H₂₄N₂O₆S₂
• 分子量: 452.552
• InChiKey: PVJJDRFKIMMPMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
  申请人：The Johns Hopkins University

  公开号：EP2586434B1

  公开（公告）日：2016-04-27
• N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors
  申请人：Toscano John P.

  公开号：US20110306614A1

  公开（公告）日：2011-12-15

  The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
• N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US20140336396A1

  公开（公告）日：2014-11-13

  The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
• US9221780B2
  申请人：——

  公开号：US9221780B2

  公开（公告）日：2015-12-29
• US9487498B2
  申请人：——

  公开号：US9487498B2

  公开（公告）日：2016-11-08