2,2',6-triethylbiphenyl | 1482498-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2',6-triethylbiphenyl
• 英文别名: 1,3-Diethyl-2-(2-ethylphenyl)benzene
• CAS: 1482498-13-4
• 化学式: C₁₈H₂₂
• 分子量: 238.373
• InChiKey: QVSRCPGQQPVCNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,6-二乙基苯胺 在 盐酸 、 potassium phosphate monohydrate 、 C₄₈H₄₅PRu 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 乙醇 、 水 为溶剂， 反应 2.33h， 生成 2,2',6-triethylbiphenyl
  参考文献：
  名称：

  An Active, General, and Long-Lived Palladium Catalyst for Cross-Couplings of Deactivated (Hetero)aryl Chlorides and Bromides with Arylboronic Acids

  摘要：

  An active, general, and long-lived palladium catalyst for Suzuki-Miyaura reactions of aryl and heteroaryl chlorides deactivated by steric hindrance, electron richness, and coordinating functional groups is reported. In reactions of arylbromide bearing two o-tert-butyl substituents, C(sp(3))-H arylation of the tert-butyl group, rather than the Suzuki-Miyaura reaction, proceeded in excellent yield. The key to the success of the reactions was the development of biphenylene-substituted dicyclohexylruthenocenylphosphine (CyR-Phos) as a supporting ligand.

  DOI：

  10.1021/jo402089r

文献信息

• HANAYA, TADASHI;YAMAMOTO, HIROSHI, BULL. CHEM. SOC. JAP., 62,(1989) N, C. 2320-2327
  作者：HANAYA, TADASHI、YAMAMOTO, HIROSHI

  DOI：——

  日期：——
• SAKURA, KATHUHIKO;TAKEUCHI, GENKI;TAKESHITA, NAOKO
  作者：SAKURA, KATHUHIKO、TAKEUCHI, GENKI、TAKESHITA, NAOKO

  DOI：——

  日期：——
• An Active, General, and Long-Lived Palladium Catalyst for Cross-Couplings of Deactivated (Hetero)aryl Chlorides and Bromides with Arylboronic Acids
  作者：Takashi Hoshi、Tomonobu Honma、Ayako Mori、Maki Konishi、Tsutomu Sato、Hisahiro Hagiwara、Toshio Suzuki

  DOI：10.1021/jo402089r

  日期：2013.11.15

  An active, general, and long-lived palladium catalyst for Suzuki-Miyaura reactions of aryl and heteroaryl chlorides deactivated by steric hindrance, electron richness, and coordinating functional groups is reported. In reactions of arylbromide bearing two o-tert-butyl substituents, C(sp(3))-H arylation of the tert-butyl group, rather than the Suzuki-Miyaura reaction, proceeded in excellent yield. The key to the success of the reactions was the development of biphenylene-substituted dicyclohexylruthenocenylphosphine (CyR-Phos) as a supporting ligand.