(E)-4-Nitro-2-((2-(dimethylamino)ethylimino)methyl)phenol | 1400582-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-4-Nitro-2-((2-(dimethylamino)ethylimino)methyl)phenol
• CAS: 1400582-28-6
• 化学式: C₁₁H₁₅N₃O₃
• 分子量: 237.258
• InChiKey: SUJLSPBNTLOFKX-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.28
• 重原子数：
  17.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  78.97
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2,2'-联吡啶 、 (E)-4-Nitro-2-((2-(dimethylamino)ethylimino)methyl)phenol 、 sodium perchlorate 、 copper(II) acetate monohydrate 以 甲醇 为溶剂， 反应 2.0h， 以80%的产率得到
  参考文献：
  名称：

  Syntheses, structures and DNA cleavage activity of NNO-tridentate Schiff base copper complexes

  摘要：

  A series of heteroleptic copper(II) complexes, [Cu((R)AIMP)(bpy)](ClO4) (1-7) and [Cu((4-OMe)QYMP)(B)] (ClO4) (B = bpy (8) or phen (9)), supported by NNO-tridentate Schiff base ligands (AIMP or QYMP) have been synthesized and characterized. X-ray crystal structural studies of complexes 1, 6 and 8, exhibit that these complexes are penta-coordinated mononuclear with a distorted square pyramidal geometry around the Cu center. Experimental results show that all of these complexes reveal good DNA cleavage activity in the presence of reducing agent 3-mercapto-propionic (MPA). However, in the photoinduced experiments at 365 nm, the activity was observed only at high concentration (200 mu M) of the Cu complexes. The 1, 10-phenanthroline coordinated complex, 9, shows the higher activity towards DNA photocleavage than its analogue complex 8 with the bipyridine base. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.07.009
• 作为产物：
  描述：

  5-硝基水杨醛 、 N,N-二甲基乙二胺 以87%的产率得到(E)-4-Nitro-2-((2-(dimethylamino)ethylimino)methyl)phenol
  参考文献：
  名称：

  Syntheses, structures and DNA cleavage activity of NNO-tridentate Schiff base copper complexes

  摘要：

  A series of heteroleptic copper(II) complexes, [Cu((R)AIMP)(bpy)](ClO4) (1-7) and [Cu((4-OMe)QYMP)(B)] (ClO4) (B = bpy (8) or phen (9)), supported by NNO-tridentate Schiff base ligands (AIMP or QYMP) have been synthesized and characterized. X-ray crystal structural studies of complexes 1, 6 and 8, exhibit that these complexes are penta-coordinated mononuclear with a distorted square pyramidal geometry around the Cu center. Experimental results show that all of these complexes reveal good DNA cleavage activity in the presence of reducing agent 3-mercapto-propionic (MPA). However, in the photoinduced experiments at 365 nm, the activity was observed only at high concentration (200 mu M) of the Cu complexes. The 1, 10-phenanthroline coordinated complex, 9, shows the higher activity towards DNA photocleavage than its analogue complex 8 with the bipyridine base. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.07.009