1-(3-methoxy-4-nitrosophenyl)pyrrolidine | 1032716-20-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-methoxy-4-nitrosophenyl)pyrrolidine
• 英文别名: 1-(3-Methoxy-4-nitrosophenyl)pyrrolidine
• CAS: 1032716-20-3
• 化学式: C₁₁H₁₄N₂O₂
• 分子量: 206.244
• InChiKey: SMBCAWBDDOVVCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  41.9
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-(3-methoxy-4-nitrosophenyl)pyrrolidine 、 3-羟基-N,N-二甲基苯胺 在 盐酸 作用下， 以 水 、 异丙醇 为溶剂， 反应 4.0h， 以70%的产率得到3-(dimethylamino)-7-(pyrrolidin-1-yl)phenoxazin-5-ium chloride
  参考文献：
  名称：

  Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives

  摘要：

  3,7-Bis(dialkylamino)phenoxazinium salts were synthesized and evaluated for in vitro activities against Plasmodium falciparum, Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani. Notably, the compounds showed potent antiprotozoal activities, especially against P. falciparum and T cruzi. The compounds with alkyl side chains less than three carbons in length possessed good activities with high selective indices.

  DOI：

  10.1021/jm8003619
• 作为产物：
  描述：

  1-(3-甲氧基苯基)-吡咯烷 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 1-(3-methoxy-4-nitrosophenyl)pyrrolidine
  参考文献：
  名称：

  Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives

  摘要：

  3,7-Bis(dialkylamino)phenoxazinium salts were synthesized and evaluated for in vitro activities against Plasmodium falciparum, Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani. Notably, the compounds showed potent antiprotozoal activities, especially against P. falciparum and T cruzi. The compounds with alkyl side chains less than three carbons in length possessed good activities with high selective indices.

  DOI：

  10.1021/jm8003619

文献信息

• Third-order nonlinear optical properties of a new type of D–π–D unsymmetrical phenoxazinium chloride with resonance structures
  作者：Jian-Feng Ge、Yue-Ting Lu、Qing-Feng Xu、Wu Liu、Na-Jun Li、Ru Sun、Ying-Lin Song、Jian-Mei Lu

  DOI：10.1016/j.chemphys.2011.02.013

  日期：2011.4

  A new series of unsymmetrical phenoxazinium chlorides, featuring a heterocyclic aromatic pi-bridge with dialkylamino donors, were evaluated in acetonitrile solution for third-order nonlinear optical properties at 532 nm using a Z-scan technique. The title compounds exhibit strong reverse saturable absorption and nonlinear refraction. The third-order nonlinear optical properties were obtained under nanosecond and picosecond laser beams. The nonlinear mechanism is revealed by the excited-state nonlinearity, as observed from a picosecond pump-probe response experiment for one of the compounds. They are potential nonlinear optical materials because they also have good solubility in polar solvents and good thermal stability. (C) 2011 Elsevier B. V. All rights reserved.