4-methyl-N-(3-methylbut-2-en-1-yl)-N-[(3-2H)prop-2-yn-1-yl]benzenesulfonamide | 1381869-98-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(3-methylbut-2-en-1-yl)-N-[(3-2H)prop-2-yn-1-yl]benzenesulfonamide
• 英文别名: N-(3-deuterioprop-2-ynyl)-4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide
• CAS: 1381869-98-2
• 化学式: C₁₅H₁₉NO₂S
• 分子量: 278.379
• InChiKey: MEAGLNLRQYMYLK-MICDWDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-N-(3-methylbut-2-en-1-yl)-N-[(3-2H)prop-2-yn-1-yl]benzenesulfonamide 、 二苯基环丙烯酮 在 [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]gold bis(trifluoromethanesulfonyl)imidate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以87%的产率得到4-(2-hydroxypropan-2-yl)-7,8-diphenyl-2-tosyl-2-azaspiro[4.4]non-7-en-6-one
  参考文献：
  名称：

  Gold(I)-Catalyzed Ring-Expanding Spiroannulation of Cyclopropenones with Enynes

  摘要：

  The gold(I)-catalyzed ring-expanding spiroannulation of cyclopropenones with enynes is reported here. A molecule of water is incorporated into the products during the spiroannulation to afford spirocyclic cyclopentenones containing an alcohol functionality.

  DOI：

  10.1021/jo500045n

文献信息

• Manganese Porphyrin Catalyzed Cycloisomerization of Enynes
  作者：Takuya Ozawa、Takuya Kurahashi、Seijiro Matsubara

  DOI：10.1021/ol301416f

  日期：2012.6.15

  Cycloisomerization of 1,6-enynes to five- or six-membered ring systems is successfully carried out in the presence of a cationic manganese(III) catalyst. The use of a structurally rigid tetradentate porphyrin as the equatorial ligand and a weakly coordinating axial ligand is the key to bringing out the catalytic reactivity of manganese for the reaction. The axial ligand of the catalyst has a marked effect on the product and selectively aids the formation of five- or six-membered cyclic products.