2-Methyl-1-(4-methylphenyl)sulfonyl-3-pentylaziridine | 960132-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-1-(4-methylphenyl)sulfonyl-3-pentylaziridine
• CAS: 960132-71-2
• 化学式: C₁₅H₂₃NO₂S
• 分子量: 281.419
• InChiKey: VYQZFSBPTGGDFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Methyl-1-(4-methylphenyl)sulfonyl-3-pentylaziridine 在 吡啶-N-氧化物 作用下， 以 甲苯 为溶剂， 反应 20.0h， 生成 4-methyl-N-(2-oxo-1-methyl-2-pentyl-ethyl)-4-methyl-benzenesulfonamide 、 4-methyl-N-(2-oxo-1-pentyl-2-methylethyl)-4-methyl-benzenesulfonamide
  参考文献：
  名称：

  通过吡啶N-氧化物使氮丙啶氧化开环，可轻松制备α-氨基酮。

  摘要：

  各种活化的氮丙啶通过吡啶N-氧化物的氧化开环反应以良好的产率提供了α-氨基酮或α-氨基醛。

  DOI：

  10.1039/b711638a
• 作为产物：
  描述：

  反-2-辛烯 、 [(N-tosylimino)iodo]benzene 在 [Cu(N,N'-bis(4-hydroxysalicylidene)phenylene-1,2-diamine)] immobilized on modified multi-wall carbon nanotubes 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以35%的产率得到2-Methyl-1-(4-methylphenyl)sulfonyl-3-pentylaziridine
  参考文献：
  名称：

  Grafting of copper(II) Schiff base complex on functionalized multi-wall carbon nanotubes: Synthesis, characterization and catalytic aziridination of olefins

  摘要：

  In this study, hydroxyl functionalized copper(II) Schiff-base; [Cu((OH)(2)-salophen)], [(OH)(2)-salophen] = (N,Ni-bis(4-hydroxysalicylidene) phenylene-1,2-diamine); has been covalently anchored on modified multi-wall carbon nanotubes (MWNTs); [Cu((OH)(2)-salophen)@MWNTs. The new modified MWNTs have been characterized by transmission electron microscopy, X-ray diffraction, thermogravimetric analysis, UV-visible spectroscopy, diffuse reflectance, Fourier transform infrared spectroscopy and elemental analysis. The results suggest that the symmetrical Schiff-base is a bivalent anion with tetradentate N2O2 donors derived from the phenolic oxygen and azomethine nitrogen. MWNTs covalently anchored copper(II) complex catalyze the aziridination of alkenes employing [N-(p-tolylsulfonyl)imino]phenyliodinane (PhI=NTs) as the nitrogen source. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2015.05.027

文献信息

• Organo-Catalytic Synthesis of 1,3-Thiazole Derivatives
  作者：Arash Khalaj、Mehdi Khalaj

  DOI：10.3184/174751916x14656621014049

  日期：2016.7

  An efficient synthesis of 1,3-thiazolidine derivatives has been achieved in which 2-pyridinecarboxaldehyde oxime was employed as a base catalyst to effect cyclisation between aziridines and CS2 in DMF at 40 °C. A similar reaction between aziridines and thiocyanates yielded 1,3-thiazoline-2-imine derivatives

  已经实现了 1,3-噻唑烷衍生物的有效合成，其中使用 2-吡啶甲醛肟作为碱催化剂，在 40°C 下在 DMF 中实现氮丙啶和 CS2 之间的环化。氮丙啶和硫氰酸酯之间的类似反应产生了 1,3-噻唑啉-2-亚胺衍生物
• Organocatalytic one-pot synthesis of functionalized 1,3-oxathiolanes and 1,3-thiazolidines
  作者：Majid Ghazanfarpour-Darjani、Alieh Khodakarami

  DOI：10.1007/s00706-015-1543-3

  日期：2016.4

  AbstractAn efficient organocatalytic approach for the synthesis of 1,3-oxathiolanes and 1,3-thiazolidines is reported. In this methodology, conjugated base of nitromethane was employed as a potential organocatalyst to promote cyclization reaction between strained heterocyclic compounds and heterocumulenes at ambient conditions. Graphical abstract

  摘要报道了一种用于合成1，3-氧杂硫杂环戊烷和1，3-噻唑烷的有效有机催化方法。在这种方法中，硝基甲烷的共轭碱被用作潜在的有机催化剂，以促进环境条件下应变杂环化合物与杂多烯之间的环化反应。 图形概要
• Tin(II) Iodide-catalyzed Selective Aziri- dination or 1,2-Diamination of Alkenes with Chloramine-T
  作者：Yoshiro Masuyama、Masaru Ohtsuka、Masaru Harima、Yasuhiko Kurusu

  DOI：10.3987/com-05-s(t)43

  日期：——

  Tin(II) iodide selectively catalyzes reactions of alkenes in acetonitrile to afford the corresponding aziridines by the use of one equimolar amount of Chloramine-T [Ts(Cl)N-] at room temperature and to afford the corresponding 1,2-diamines by the use of excess Chloramine-T at 50 degrees C.
• Tributylphosphine-Catalyzed Cycloaddition of Aziridines with Carbon Disulfide and Isothiocyanate
  作者：Jing-Yu Wu、Zhi-Bin Luo、Li-Xin Dai、Xue-Long Hou

  DOI：10.1021/jo801703h

  日期：2008.11.21

  Aziridines underwent cyclization reaction with carbon disulfide and isothiocyanate in the presence of organophosphine to afford thiazolidinone derivatives in good to high yields. The mechanistic study revealed that organophosphine serves as a catalyst in the reaction.