4-chloro-N-(4-ethylbenzyl)aniline | 852851-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-(4-ethylbenzyl)aniline
• 英文别名: 4-chloro-N-[(4-ethylphenyl)methyl]aniline
• CAS: 852851-51-5
• 化学式: C₁₅H₁₆ClN
• mdl: MFCD06682697
• 分子量: 245.752
• InChiKey: FEDNWDLSPLPTTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 4-乙基苯甲醛 在 gallium(III) triflate 、 三乙基硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 3.5h， 以95%的产率得到4-chloro-N-(4-ethylbenzyl)aniline
  参考文献：
  名称：

  Gallium(III) Triflate Catalyzed Direct Reductive Amination of Aldehydes

  摘要：

  Direct hydroamination of aldehydes and ketones provides one-step entry into desired alpha-aminoalkane derivatives which are important synthons for many biologically active molecules. The reductive amination of aldehydes in the presence of silanes has been effectively promoted by Ga(OTf)(3) as a catalyst. Mild conditions, easy work-up and high purity of products with excellent yields are the major advantages of this method.

  DOI：

  10.1007/s10562-010-0347-7

文献信息

• Gallium(III) Triflate Catalyzed Direct Reductive Amination of Aldehydes
  作者：G. K. Surya Prakash、Clement Do、Thomas Mathew、George A. Olah

  DOI：10.1007/s10562-010-0347-7

  日期：2010.7

  Direct hydroamination of aldehydes and ketones provides one-step entry into desired alpha-aminoalkane derivatives which are important synthons for many biologically active molecules. The reductive amination of aldehydes in the presence of silanes has been effectively promoted by Ga(OTf)(3) as a catalyst. Mild conditions, easy work-up and high purity of products with excellent yields are the major advantages of this method.