(3S,3aR,6R,6aR)-3,6-bis[(2-methylpropan-2-yl)oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan | 1426840-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: (3S,3aR,6R,6aR)-3,6-bis[(2-methylpropan-2-yl)oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
• CAS: 1426840-24-5
• 化学式: C₁₄H₂₆O₄
• 分子量: 258.358
• InChiKey: FGSLSAHHYSIVFG-WRWGMCAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异丁烯 、 异山梨醇 在 Amberlyst-15 作用下， 以 乙酸乙酯 为溶剂， 反应 6.0h， 生成 (3R,3aR,6S,6aR)-6-(tert-butoxy)hexahydrofuro[3,2-b]furan-3-ol 、 (3S,3aR,6R,6aR)-3,6-bis[(2-methylpropan-2-yl)oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan 、 (3S,3aR,6R,6aR)-6-(tert-butoxy)hexahydrofuro[3,2-b]furan-3-ol
  参考文献：
  名称：

  Heterogeneously catalysed production of isosorbide tert-butyl ethers

  摘要：

  异山梨醇叔丁基醚（ITBE）是通过酸性离子交换树脂催化生物异山梨醇与叔丁醇以及异丁烯的醚化反应生成的高沸点液体。

  DOI：

  10.1039/c3cy20752h

文献信息

• Reaction network analysis and continuous production of isosorbide tert-butyl ethers
  作者：Rebecca Pfützenreuter、Marta Helmin、Stefan Palkovits、Regina Palkovits、Marcus Rose

  DOI：10.1016/j.cattod.2014.03.007

  日期：2014.10

  investigated the formation of the respective tert-butyl ethers by an addition reaction of isosorbide to isobutene heterogeneously catalyzed by acidic ion exchange resins. An efficient liquid phase process under ambient conditions in a batch reactor has been developed. The reaction network was unravelled by detailed investigation of the reaction kinetics. Additionally, the feasibility of continuous

  异山梨醇被认为是用于生产化学品的多功能生物平台化合物。其两个羟基的功能化具有挑战性，因为它们表现出不同的构型，因此具有不同的反应性和空间可及性。我们研究了异山梨醇与异丁烯在酸性离子交换树脂的非均相催化下的加成反应，从而形成了相应的叔丁基醚。已经开发了在间歇反应器中在环境条件下的有效液相方法。通过详细研究反应动力学来分解反应网络。此外，连续处理的可行性已在实验室规模上成功地证明了使用连续搅拌釜式反应器的可行性。
• Isoxazole analogs as FXR agonists and methods of use thereof
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10689391B2

  公开（公告）日：2020-06-23

  The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

  本发明提供了式 (I) 的化合物、 及其药学上可接受的盐，以及包含这些化合物的药物组合物和使用这些化合物预防或治疗 FXR 介导或 TGR5 介导的疾病或病症的方法。
• Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
  申请人：Trustees of Boston College

  公开号：US11186678B2

  公开（公告）日：2021-11-30

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  本研究提供了可实现序列控制的开环聚合和开环聚合的自由基级联反应，用于受控合成具有复杂主链结构的聚合物。此外，还提供了简便的合成方法，从而获得由开环触发器和扩展主链结构组成的低应变大环单体。本公开进一步提供了对聚合物分子量和分子量分布进行出色控制的方法，高链端保真度使得制备具有明确结构的聚合物体系成为可能。此外，还提供了聚合物化学中自由基级联触发转化的一般性质，及其在合成具有定制功能的各种主链结构基团的聚合物中的应用。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。
• RADICAL CASCADE-ENABLED SYNTHESIS OF PRECISION POLYMERS WITH COMPLEX MAIN-CHAIN STRUCTURES
  申请人：Trustees of Boston College

  公开号：US20200216610A1

  公开（公告）日：2020-07-09

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.