(SP-4-1)-[29H,31H-酞菁-2,9,16,23-四胺基(2-)-ΚN29,ΚN30,ΚN31,ΚN32]锌 | 84097-37-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: (SP-4-1)-[29H,31H-酞菁-2,9,16,23-四胺基(2-)-ΚN29,ΚN30,ΚN31,ΚN32]锌
• 英文名称: zinc tetraaminophthalocyanine
• 英文别名: ZINC;2,11,20,29,37,38-hexaza-39,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1(37),2,4(9),5,7,10,12,14,16,18,20,22(27),23,25,28(38),29,31(36),32,34-nonadecaene-6,15,24,33-tetramine；zinc;2,11,20,29,37,38-hexaza-39,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1(37),2,4(9),5,7,10,12,14,16,18,20,22(27),23,25,28(38),29,31(36),32,34-nonadecaene-6,15,24,33-tetramine
• CAS: 84097-37-0
• 化学式: C₃₂H₂₀N₁₂Zn
• 分子量: 637.981
• InChiKey: UOTOIJASJLCEQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.45
• 重原子数：
  45
• 可旋转键数：
  0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  180
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  (SP-4-1)-[29H,31H-酞菁-2,9,16,23-四胺基(2-)-ΚN29,ΚN30,ΚN31,ΚN32]锌 在 吡啶 、 吡啶盐酸盐 作用下， 反应 17.0h， 以95%的产率得到2,9,16,23-tetraaminophthalocyanine
  参考文献：
  名称：

  [EN] PREPARATION AND USES OF GUANIDINIUM-MODIFIED PORPHYRINS AND PHTHALOCYANINES
  [FR] PRÉPARATION ET UTILISATIONS DE PORPHYRINES ET PHTALOCYANINES MODIFIÉES PAR LA GUANIDINE

  摘要：

  公开号：

  WO2010028780A3
• 作为产物：
  描述：

  zinc tetranitrophthalocyanine 在 sodiumsulfide nonahydrate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (SP-4-1)-[29H,31H-酞菁-2,9,16,23-四胺基(2-)-ΚN29,ΚN30,ΚN31,ΚN32]锌
  参考文献：
  名称：

  Synthesis and Spectral Studies on Substituted Metal (II)-Tetra-1-(Thiophene-2-yl)methanimine Phthalocyanine Complexes

  摘要：

  通过四氨基酞菁与2-噻吩甲醛的缩合反应合成了对称取代的过渡金属(II) - 四-1-(噻吩-2-基)亚甲基咔唑酞菁络合物，并进行了表征。利用FT-红外光谱、UV-Vis光谱、XRD、磁性测量和热重分析等多种分析技术阐明了蓝色四-1-(噻吩-2-基)亚甲基咔唑酞菁络合物的结构和特性。热重分析数据用于计算合成酞菁络合物的动力学参数和热分解特性。

  DOI：

  10.13005/ojc/340344

文献信息

• Metallophthalocyanine-based redox active metal–organic conjugated microporous polymers for OER catalysis
  作者：Ashish Singh、Syamantak Roy、Chayanika Das、Debabrata Samanta、Tapas Kumar Maji

  DOI：10.1039/c8cc01291a

  日期：——

  We report the design and synthesis of two Co2+ and Zn2+ phthalocyanine (PC)-based redox active metal–organic conjugated microporous polymers (MO-CMP), CoCMP and ZnCMP, respectively, obtained by a Schiff base condensation reaction. CoCMP, where Co2+ is stabilized by N4-coordination of PC, has shown stable and efficient electrocatalytic activity towards the OER with a low overpotential of 340 mV.

  我们报道了通过席夫碱缩合反应获得的两种基于Co 2+和Zn 2+酞菁（PC）的氧化还原活性金属-有机共轭微孔聚合物（MO-CMP）的设计和合成。通过PC的N4配位使Co 2+稳定的CoCMP对OER表现出稳定而有效的电催化活性，其低电势为340 mV。
• Synthesis of new zinc (II) phthalocyanine conjugates with block copolymers for cancer therapy
  作者：Łukasz Lamch、Marta Tsirigotis-Maniecka、Julita Kulbacka、Kazimiera A. Wilk

  DOI：10.24820/ark.5550190.p009.764

  日期：——

  Synthetic routes towards new conjugates of hydrophilic zinc(II) phthalocyanine (ZnPc) with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic P123) and poly(L-lactide) (PLLA), are described. The main semiproduct ZnPc was obtained by heating 4-nitrophthalimide with urea and zinc chloride, followed by the reduction step. Steglich esterification was used to synthesize two ZnPc-conjugated

  亲水锌（II）酞菁（ZnPc）与聚（环氧乙烷）-b-聚（环氧丙烷）-b-聚（环氧乙烷）（Pluronic P123）和聚（L-丙交酯）（PLLA）的新型共轭物的合成路线), 进行了描述。通过将 4-硝基邻苯二甲酰亚胺与尿素和氯化锌一起加热，然后进行还原步骤，获得主要的半成品 ZnPc。Steglich 酯化用于合成两种 ZnPc 共轭嵌段共聚物，进一步用于制造用锌 (II) 酞菁型部分功能化的聚合物胶束 (PM)。PM的生物学评估表明符合纳米治疗学和纳米医学领域的要求的可接受的生物相容性水平。
• Synthesis and photoactivity of pH-responsive amphiphilic block polymer photosensitizer bonded zinc phthalocyanine
  作者：WangYang Lü、ChunMei Sun、Qin Lu、Nan Li、DeZhou Wu、YuYuan Yao、WenXing Chen

  DOI：10.1007/s11426-011-4444-2

  日期：2012.6

  A zinc tetraaminophthalocyanine derivative, zinc tetra(methacryloyl moiety)aminophthalocyanine (MeZnAPc) (with a double bond) was synthesized by the reaction between zinc tetraaminophthalocyanine (ZnTAPc) and methacryloyl chloride. Atom transfer radical polymerization (ATRP) was employed as the polymerization technique to obtain a novel pH-responsive polymeric photosensitizer (PEG110-b-P(DPA n -co-MeZnAPc m )) by copolymerizing of methoxypolyethylene glycols (MPEG) (as reducing agent), 2-(isopropylamino)ethyl methacrylate (DPA) and MeZnAPc. This photosensitizer was characterized by UV-vis spectroscopy, FTIR, 1H NMR, etc. The results indicated that the photosensitizer presented the well pH-responsive behavior around the pH range 6.0–6.5 and the high photoactivity to 1,3-diphenylisobenzofuran (DPBF). The result of photocatalysis oxidation of l-tryptophan (l-Try) suggested that zinc phthalocyanine could present high photoactivity due to its dispersivity at pH 5.5 without formation of micelles, and its photoactivity decreased dramatically at pH 7.4 due to wrapping ZnTAPc into the micelles. Therefore, the novel pH-responsive polymeric photosensitizer has better application prospects in the field of photodynamic therapy.

  由四氨基酞菁锌（ZnTAPc）和甲基丙烯酰氯反应合成了一种四氨基酞菁锌衍生物--四（甲基丙烯酰基）氨基酞菁锌（MeZnAPc）（具有双键）。采用原子转移自由基聚合（ATRP）聚合技术，通过甲氧基聚乙二醇（MPEG）（作为还原剂）、2-（异丙基氨基）乙基甲基丙烯酸酯（DPA）和 MeZnAPc 的共聚，得到了一种新型 pH 响应型聚合物光敏剂（PEG110-b-P(DPA n -co-MeZnAPc m )）。该光敏剂通过紫外-可见光谱、傅立叶变换红外光谱、1H NMR 等方法进行了表征。结果表明，该光敏剂在 6.0-6.5 的 pH 值范围内具有良好的 pH 值响应行为，对 1,3-二苯基异苯并呋喃（DPBF）具有很高的光活性。对 l-色氨酸（l-Try）的光催化氧化结果表明，酞菁锌在 pH 值为 5.5 时，由于其分散性，不会形成胶束，因此光活性较高；而在 pH 值为 7.4 时，由于 ZnTAPc 包裹在胶束中，光活性急剧下降。因此，这种新型 pH 响应聚合物光敏剂在光动力疗法领域具有更好的应用前景。
• Synthesis and Characterization of Metal (II) Phthalocyanine Containing N, N-Dimethyl Phenyl Moieties
  作者：Fasiulla Fasiulla

  DOI：10.13005/ojc/380506

  日期：2022.10.31

  Synthesized of novel metal (II)- tetra-4-(N,N-dimethyl phenyl) methan-imine phthalocyanines (MTDMPhImPc) [ M = Co, Ni, Cu, Zn] by an effective and suitable method. The tetra-nitrophthalocyanines converted into aminophthalocyanines by reduction. Than amino phthalocyanines derivatives bearing tetra-4-(N,N-dimethyl phenyl) to form tetra substituted 4-(N,N-dimethyl phenyl) methane-imine phthalocyanines complexes. These derivatives compounds were characterized by FTIR, elemental analysis, magnetic and powder XRD properties to check the purity and structural integrity. Magnetic measurements on copper and cobalt substituted phthalocyanine complexes in the range of magnetic strength 2.21 to 4.02 kG that a variation of field strength with magnetic moments due to the presence of an intermolecular cooperative effect

  采用一种有效而合适的方法合成了新型金属（II）-四-4-（N,N-二甲基苯基）甲亚胺酞菁（MTDMPhImPc）[M = Co、Ni、Cu、Zn]。四硝基酞菁通过还原作用转化为氨基酞菁。这些氨基酞菁衍生物含有四-4-（N,N-二甲基苯基），形成四取代的 4-（N,N-二甲基苯基）甲烷-亚胺酞菁配合物。通过傅立叶变换红外光谱、元素分析、磁性和粉末 XRD 特性对这些衍生物化合物进行了表征，以检查其纯度和结构完整性。在磁场强度为 2.21 至 4.02 kG 的范围内，对铜和钴取代的酞菁配合物进行了磁性测量，结果表明，由于分子间合作效应的存在，磁场强度随磁矩的变化而变化。
• Synthesis and evaluation of antibacterial activity of water-soluble copper, nickel and zinc tetra (n-carbonylacrylic) aminephthalocyanines
  作者：P. A. Pavaskar、S. S. Patil、I. Furtado、A. V. Salker

  DOI：10.1007/s00044-012-0427-x

  日期：2013.9

  Water-soluble copper, nickel, and zinc tetra (n-carbonylacrylic) aminephthalocyanines were synthesized with an aim to evaluate their role as therapeutic materials. They were characterized by UV-Vis spectrophotometer, infra-red spectra, elemental analysis, nuclear magnetic resonance, and thermogravimetry. Efforts were made to optimize the synthesis of intermediates and final products. Photoluminescence studies were carried out on these compounds. The investigation of antibacterial activity of these aqueous soluble phthalocyanines was carried out on Staphylococcus citreus, Serratia marcescens, Proteus vulgaris, Bacillus subtilis, and Pseudomonas fluorescence, showed good inhibitory activity.