2,4-dimethyl-2-phenyl-valeronitrile | 4355-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dimethyl-2-phenyl-valeronitrile
• 英文别名: 2,4-Dimethyl-2-phenyl-valeronitril；Isobutylphenyl propionitrile；2,4-dimethyl-2-phenylpentanenitrile
• CAS: 4355-51-5
• 化学式: C₁₃H₁₇N
• 分子量: 187.285
• InChiKey: OXUWQJSAPOXFAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异丁基苯基酮 在 bis(1,5-cyclooctadiene)nickel (0) 、 potassium tert-butylate 、 C₇₆H₆₀O₁₀P₂ 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 19.0h， 生成 2,4-dimethyl-2-phenyl-valeronitrile
  参考文献：
  名称：

  镍催化的α-取代的苯乙烯的Markovnikov氢氰化反应合成叔苄腈。

  摘要：

  α-取代的苯乙烯的马尔科夫尼科夫氢氰化能够在镍催化下合成叔苄腈。无路易斯酸的转化具有前所未有的官能团耐受性，包括-OH和-NH2基团。以良好至优异的产率获得了广泛的叔苄腈。另外，初步研究了该反应的不对称形式。

  DOI：

  10.1021/acs.orglett.9b04554

文献信息

• High- and moderately high-methionine uptake demonstrated by PET in a patient with a subacute cerebral infarction
  作者：Atsuko Nagano-Saito、Takashi Kato、Toshihiko Wakabayashi、Masanari Nishino、Motonori Ohshima、Kengo Ito、Tsumeo Ishiguchi、Masanori Tadokoro、Takeo Ishigaki、Yuji Abe、Masahiko Bundo

  DOI：10.1007/bf02988250

  日期：2001.8

  In patients with cerebral tumors, high accumulations of L-methyl-C-11-methionine (C-11-Met) have been reported in some cases of cerebral ischemic disease, but no high accumulations of C-11-Met in areas where only transient arterial occlusions are most likely to occur have been reported. Herein we present a case of a high accumulation of C-11-Met in an area of frontal interhemispheric cerebral infarction and a moderately high accumulation with an unclear margin in a distant frontal convexity area. A craniotomy revealed a subacute stage of cerebral infarction in the interhemispheric lesion, and an ischemic change in the distant convexity area. Sixteen months after onset, CT scans demonstrated an infarction area in the interhemispheric lesion only, and no atrophic changes were observed in the distant convexity area indicating that no serious tissue damage had occurred.