(R)-N2-Methyl-3-[(R)-2-methylamino-3-((S)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((S)-1-phenyl-ethyl)-propane-1,2-diamine | 448927-82-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-N2-Methyl-3-[(R)-2-methylamino-3-((S)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((S)-1-phenyl-ethyl)-propane-1,2-diamine
• CAS: 448927-82-0
• 化学式: C₂₄H₃₈N₄S₂
• 分子量: 446.725
• InChiKey: LAQBZZPQVIAAAQ-UWXQAFAOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  30.0
• 可旋转键数：
  15.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.12
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 (R)-N2-Methyl-3-[(R)-2-methylamino-3-((S)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((S)-1-phenyl-ethyl)-propane-1,2-diamine 以 苯 为溶剂， 生成 (4R)-3-methyl-4-[[[(4R)-3-methyl-1-[(1S)-1-phenylethyl]imidazolidin-4-yl]methyldisulfanyl]methyl]-1-[(1S)-1-phenylethyl]imidazolidine
  参考文献：
  名称：

  Synthesis of new chiral imidazolidine disulfides derived from l-cystine and their application in the enantioselective addition of diethylzinc to aldehydes

  摘要：

  Several chiral imidazolidine disulfides 4a-d derived from L-cystine have been synthesized. These ligands have been applied as chiral catalysts in the asymmetric addition of diethylzinc to aldehydes. The best results were obtained by employing 5 mol%,, of imidazolidine disulfide 4a, and chiral secondary alcohols were obtained in up to 91% e.e. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00300-3
• 作为产物：
  描述：

  L-胱氨酸 在 N-甲基吗啉 、 sodium hydroxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 生成 (R)-N2-Methyl-3-[(R)-2-methylamino-3-((S)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((S)-1-phenyl-ethyl)-propane-1,2-diamine
  参考文献：
  名称：

  Synthesis of new chiral imidazolidine disulfides derived from l-cystine and their application in the enantioselective addition of diethylzinc to aldehydes

  摘要：

  Several chiral imidazolidine disulfides 4a-d derived from L-cystine have been synthesized. These ligands have been applied as chiral catalysts in the asymmetric addition of diethylzinc to aldehydes. The best results were obtained by employing 5 mol%,, of imidazolidine disulfide 4a, and chiral secondary alcohols were obtained in up to 91% e.e. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00300-3