2-Bromo-1-(2-bromoethynyl)-4-chlorobenzene | 1519058-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Bromo-1-(2-bromoethynyl)-4-chlorobenzene
• CAS: 1519058-72-0
• 化学式: C₈H₃Br₂Cl
• 分子量: 294.373
• InChiKey: PYORWSZIBBKEJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  四氢噻吩 、 2-Bromo-1-(2-bromoethynyl)-4-chlorobenzene 反应 24.0h， 以90%的产率得到((2-bromo-4-chlorophenyl)ethynyl)(4-bromobutyl)sulfane
  参考文献：
  名称：

  Dual Role of Alkynyl Bromides in One-Step Synthesis of Bromo-Substituted Alkynyl Sulfides

  摘要：

  An atom-economical and environmentally friendly method for synthesis of bromo-substituted alkynyl sulfides has been developed. In the absence of any additive, alkynyl bromides could react with tetrahydrothiophene to give bromo-substituted alkynyl sulfides in moderate to perfect yields.

  DOI：

  10.1080/00397911.2014.958783

文献信息

• Synthesis of 2-Alkynyltetrahydrofuran Derivatives from Tetrahydrofuran and Alkynyl Bromides
  作者：Yun Liang、Yuan Yang、Hui Huang、Xiaoyun Zhang、Weilan Zeng

  DOI：10.1055/s-0033-1338534

  日期：——

  An efficient and general method for the synthesis of 2-alkynyltetrahydrofuran was developed. The regioselective functionalization of the C(sp(3))-H bond adjacent to an oxygen atom with various alkynyl bromides has been achieved under transition-metal-free reaction conditions. Sodium fluoride was found, for the first time, to promote the efficient functionalization process remarkably. Moreover, 1,2-dibromostyrenes were also found to be effective in this method forming 2-alkenyltetrahydrofurans.