6-hemisuccinoxycortisol | 132882-95-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6-hemisuccinoxycortisol
• 英文别名: 4-[[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4-oxobutanoic acid
• CAS: 132882-95-2
• 化学式: C₂₅H₃₄O₉
• 分子量: 478.54
• InChiKey: YWDXYWYTWPJTHZ-JNWJKYDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  158
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  3-methoxy-11β,17,21-trihydroxy-Δ^3,5-pregnadien-20-one 17,21-acetonide 在 吡啶 、 溶剂黄146 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 5.0h， 生成 6-hemisuccinoxycortisol
  参考文献：
  名称：

  Preparation of europium-labeled derivatives of cortisol for time-resolved fluoroimmunoassays

  摘要：

  Cortisol 3-(O-carboxymethyl)oxime, 6- and 21-hemisuccinoxycortisol, and cortisol 7-carboxyethyl thioether were synthesized. These carboxyl derivatives were labeled using a described general labeling method with an europium chelate. The labeled steroids were tested in a competitive time-resolved fluoroimmunoassay using antibodies raised against cortisol. Only the site-homologous antigen-antibody pairs underwent immunoreaction and gave satisfactory calibration curves.

  DOI：

  10.1016/0039-128x(91)90109-9