17α-Aethinyl-3-methyl-oestra-1,3,5(10)-trien-17β-ol | 2529-55-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17α-Aethinyl-3-methyl-oestra-1,3,5(10)-trien-17β-ol
• 英文别名: (8R,9S,13S,14S,17R)-17-ethynyl-3,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
• CAS: 2529-55-7
• 化学式: C₂₁H₂₆O
• 分子量: 294.437
• InChiKey: FBDWRVRRTCUBJP-MJCUULBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  17α-Aethinyl-3-methyl-oestra-1,3,5(10)-trien-17β-ol 在 Lindlar's catalyst 吡啶 、 氢气 作用下， 生成 17α-Vinyl-3-methyl-oestra-1.3.5(10)-trien-17β-ol
  参考文献：
  名称：

  一些3-脱氧雌三烯酮的制备和药理作用。脂质转移和雌激素作用。

  摘要：

  DOI：

  10.1021/jm00328a001
• 作为产物：
  描述：

  诺龙 在 chromium(VI) oxide 、 氢氧化钾 、 硫酸 、 potassium 2-methylbutan-2-olate 作用下， 生成 17α-Aethinyl-3-methyl-oestra-1,3,5(10)-trien-17β-ol
  参考文献：
  名称：

  一些3-脱氧雌三烯酮的制备和药理作用。脂质转移和雌激素作用。

  摘要：

  DOI：

  10.1021/jm00328a001

文献信息

• HYDROXIDE-CATALYZED FORMATION OF SILICON-OXYGEN BONDS BY DEHYDROGENATIVE COUPLING OF HYDROSILANES AND ALCOHOLS
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US20170029447A1

  公开（公告）日：2017-02-02

  The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate having at least one organic alcohol moiety with a mixture of at least one hydrosilane and sodium and/or potassium hydroxide, the contacting resulting in the formation of a dehydrogenatively coupled silyl ether. The disclosure further described associated compositions and methods of using the formed products.

  本公开涉及一种将脱氢偶联的氢硅烷和醇的方法，所述方法包括将至少具有一个有机醇基团的有机底物与至少一种氢硅烷和氢氧化钠和/或氢氧化钾的混合物接触，所述接触导致形成脱氢偶联的硅醚。该公开还描述了相关的组合物和使用所形成产品的方法。
• BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US20160060278A1

  公开（公告）日：2016-03-03

  The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.

  本发明涉及一种温和、高效且通用的直接C(sp)-H键硅化方法。各种实施例包括方法，每种方法包括或主要包括将至少一种含有末端炔基C—H键的有机底物与至少一种有机硅烷和碱金属氢氧化物的混合物接触，条件足以形成硅化的末端炔基基团。这些方法在基本上不含过渡金属化合物的情况下可操作。与这些方法相关的系统也被揭示。
• CONJUGATED SMALL MOLECULES
  申请人：Grotzfeld Robert M.

  公开号：US20100048890A1

  公开（公告）日：2010-02-25

  Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.

  本文提供了链接剂化合物和包括该链接剂化合物的共轭物。在一种实施例中，该链接剂化合物包括2或3个6-氨基己酸残基和可选的7-10个聚乙二醇（PEG）残基。该链接剂化合物有用于与在生物制药或生物分析应用中有用的一个或多个组分形成共轭物。特别是，生物制药上有用的化合物是激酶抑制剂。本文所描述的共轭物在各种诊断、分离和治疗应用中具有实用性。
• Derivative prodrugs of ethinyl estradiol
  申请人：Keown James

  公开号：US20070015740A1

  公开（公告）日：2007-01-18

  The present invention is a prodrug derivative of ethinyl estradiol according to Formula I:
• US7795241B2
  申请人：——

  公开号：US7795241B2

  公开（公告）日：2010-09-14