11,21-dihydroxy-17-[1-oxo-3-(phenylsulfonyl)propoxy]-(11β)-pregn-4-ene-3,20-dione | 1432795-55-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 11,21-dihydroxy-17-[1-oxo-3-(phenylsulfonyl)propoxy]-(11β)-pregn-4-ene-3,20-dione
• 英文别名: [(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] 3-(benzenesulfonyl)propanoate
• CAS: 1432795-55-5
• 化学式: C₃₀H₃₈O₈S
• 分子量: 558.693
• InChiKey: GAIFOUJQERPYJB-WXWSXMEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  11,21-dihydroxy-17-[1-oxo-3-(phenylthio)propoxy]-(11β)-pregn-4-ene-3,20-dione 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以12.5 g的产率得到11,21-dihydroxy-17-[1-oxo-3-(phenylsulfonyl)propoxy]-(11β)-pregn-4-ene-3,20-dione
  参考文献：
  名称：

  [EN] PARTICLES, COMPOSITIONS, AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS
  [FR] PARTICULES, COMPOSITIONS ET PROCÉDÉS POUR APPLICATIONS OPHTALMIQUES ET/OU AUTRES APPLICATIONS

  摘要：

  本公开涉及有助于粘液中颗粒运输的颗粒、组合物和方法。这些颗粒、组合物和方法在某些情况下可用于眼科和/或其他应用。

  公开号：

  WO2018053321A1

文献信息

• 4-PREGENEN-11BETA-17-21-TRIOL-3,20-DIONE DERIVATIVES
  申请人：Allergan, Inc.

  公开号：US20130123223A1

  公开（公告）日：2013-05-16

  The present invention relates to novel 4-pregenen-11β-17-21-triol-3,20-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, as modulators of glucocorticoid or mineralocorticoid receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with glucocorticoid or mineralocorticoid receptor modulation.

  本发明涉及新型的4-孕烷-11β-17-21-三醇-3,20-二酮衍生物，其制备方法，包含它们的制药组合物以及它们作为药物的用途，作为糖皮质激素或醛固酮受体调节剂。本发明具体涉及这些化合物及其制药组合物用于治疗与糖皮质激素或醛固酮受体调节相关的疾病。
• 4-PREGENEN-11SS-17-21-TRIOL-3,20-DIONE DERIVATIVES FOR THE TREATMENT OF OCULAR CONDITIONS
  申请人：ALLERGAN, INC.

  公开号：EP2776040B1

  公开（公告）日：2020-04-22
• SELF-EMULSIFYING DRUG DELIVERY (SEDDS) FOR OPHTHALMIC DRUG DELIVERY
  申请人：Allergan, Inc.

  公开号：US20180036233A1

  公开（公告）日：2018-02-08

  Provided herein are topical ophthalmic preparations which comprise a non-aqueous, self-emulsifying system which can spontaneously give rise to either nanosized emulsions upon contact with an aqueous phase. Also provided herein are methods for the preparation of the same and their use in formulating and delivering poorly water soluble drugs.
• Particles, Compositions and Methods for Ophthalmic and/or Other Applications
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20190216726A1

  公开（公告）日：2019-07-18

  This disclosure relates to particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications.
• US8906892B2
  申请人：——

  公开号：US8906892B2

  公开（公告）日：2014-12-09