Sophocarpin | 1089764-87-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: Sophocarpin
• 英文别名: 7,13-Diazatetracyclo[7.7.1.02,7.013,17]heptadec-4-en-6-one
• CAS: 1089764-87-3
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: AAGFPTSOPGCENQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MATRINIC ACID/MATRINE DERIVATIVES AND PREPARATION METHODS AND USES THEREOF
  申请人：Jiang Jiandong

  公开号：US20130190345A1

  公开（公告）日：2013-07-25

  The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/or AIDS.

  本发明涉及一种N-取代马陈酸衍生物或马陈衍生物，以及其制备方法和用途。具体地，本发明涉及一种化合物的化合物（其中所有取代基的定义均为规范中提到的那些），或其药学上可接受的盐、几何异构体、立体异构体、溶剂合物、酯或前药。本发明还涉及一种制备本发明化合物的方法，含有该化合物的药物组合物，以及在制造药物中使用的用途。本发明的化合物可用于预防和/或治疗与病毒感染相关的疾病或紊乱，如乙型肝炎和/或丙型肝炎和/或艾滋病。
• MATRINIC ACID/ MATRINE DERIVATIVES AND PREPARATION METHODS AND USES THEREOF
  申请人：Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

  公开号：EP2581376A1

  公开（公告）日：2013-04-17

  The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/orAIDS.

  本发明涉及一种 N-取代的马钱子酸衍生物或马钱子碱衍生物及其制备方法和用途。具体地说，本发明涉及一种式（I）或（II）化合物（其中所有取代基团的定义均为说明书中提及的定义），或其药学上可接受的盐、几何异构体、立体异构体、溶液、酯或原药。本发明还涉及一种制备本发明化合物的方法、一种含有本发明化合物的药物组合物及其在制造药物中的用途。本发明化合物可用于预防和/或治疗与病毒感染有关的疾病或紊乱，如乙型肝炎和/或丙型肝炎和/或艾滋病。