benzoylecgonine | 1130667-83-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoylecgonine
• 英文别名: O-Benzoylecgonin；3-benzoyloxy-8-methyl-nortropane-2-carboxylic acid；3-Benzoyloxy-tropan-2-carbonsaeure；3-(-Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid；3-benzoyloxy-8-methyl-8-azoniabicyclo[3.2.1]octane-2-carboxylate
• CAS: 1130667-83-2
• 化学式: C₁₆H₁₉NO₄
• 分子量: 289.331
• InChiKey: GVGYEFKIHJTNQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  benzoylecgonine 、 甲醇 生成 cocaine
  参考文献：
  名称：

  NADIG, D. E.;BADESSO, R. J., PITTSBURGH CONF. AND EXPO. ANAL. CHEM. AND APPL. SPECTROSC., NEW ORLEANS,+

  摘要：

  DOI：

文献信息

• Compounds and compositions for treating infection
  申请人：Chepkwony Paul Kiprono

  公开号：US20090069277A1

  公开（公告）日：2009-03-12

  Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.

  来自14种肯尼亚植物的化合物，包括 Dovyalis abyssinica 和 Clutia robusta 的根部已经被鉴定和分离，它们的用途也被公开了。
• COMPOUNDS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：Chepkwony Paul Kiprono

  公开号：US20120190734A1

  公开（公告）日：2012-07-26

  Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.

  来自14种肯尼亚植物的化合物已经被鉴定和分离，包括来自阿比西尼亚多维亚利斯和强健小簇花的根部，它们的用途已经被披露。
• Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
  申请人：Xenova Research Limited

  公开号：US20030069400A1

  公开（公告）日：2003-04-10

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明公开了能够通过在治疗组合物中给予而在体内引发抗半抗原抗体的半抗原-载体偶联物。本发明还公开了制备该偶联物和治疗组合物的方法。当半抗原是一种药物成瘾时，含有半抗原-载体偶联物的治疗组合物在治疗药物成瘾，尤其是可卡因成瘾方面特别有用。还公开了使用针对本发明偶联物所产生的抗体进行被动免疫的方法。该治疗组合物适用于与其他常规药物一起进行联合治疗。
• Hapten-carrier conjugates for use in drug abuse therapy and methods for preparation of same
  申请人：Swain Philip A.

  公开号：US20100068222A1

  公开（公告）日：2010-03-18

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明揭示了能够通过在治疗组合物中给予而在体内引起抗卟胶原抗体的卟胶原载体共轭物。本发明还揭示了制备该共轭物和治疗组合物的方法。当卟胶原是一种药物滥用物时，含有卟胶原载体共轭物的治疗组合物在治疗药物成瘾，更特别地，在可卡因成瘾的治疗中特别有用。本发明还揭示了使用针对本发明共轭物所提高的抗体进行被动免疫的方法。该治疗组合物适用于与其他传统药物联合治疗。
• HAPTEN-CARRIER CONJUGATES FOR USE IN DRUG-ABUSE THERAPY AND METHODS FOR PREPARATION OF SAME
  申请人：Swain Philip A.

  公开号：US20100209449A1

  公开（公告）日：2010-08-19

  Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

  本发明揭示了能够通过在治疗组合物中给予而在体内引发抗卟胶原抗体的卟胶原载体共轭物。本发明还揭示了制备该共轭物和治疗组合物的方法。当卟胶原是药物滥用时，含有卟胶原载体共轭物的治疗组合物在治疗药物成瘾，特别是可卡因成瘾方面特别有用。本发明还揭示了使用针对本发明共轭物所产生的抗体进行被动免疫的方法。该治疗组合物适用于与其他传统药物联合治疗。