2-[3-[1-[[2-(3,4-Dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-[1-[[2-(3,4-Dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid
• 化学式: C₂₃H₂₆Cl₂N₂O₄
• 分子量: 465.4
• InChiKey: JKYJSFISYHSNOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Methods and compositions for treating vasomotor symptoms
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US11083726B2

  公开（公告）日：2021-08-10

  The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.

  本公开总体上涉及用于治疗或限制受试者血管运动症状发展的组合物和方法。
• Peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response
  申请人：Caventure Drug Discovery, Inc.

  公开号：US11185551B2

  公开（公告）日：2021-11-30

  The present disclosure teaches the use of a dual-acting opioid agonist for the treatment of pain (e.g., inflammatory pain). The opioid agonist activates both the kappa and delta opioid receptors to provide synergistic reduction in pain. The opioid agonist is peripherally restricted and does not cross the blood-brain barrier.

  本公开教导使用双效阿片激动剂治疗疼痛（如炎性疼痛）。这种阿片激动剂可同时激活卡巴和δ阿片受体，从而协同减轻疼痛。阿片受体激动剂受外周限制，不能穿过血脑屏障。
• PHARMACEUTICAL COMPOSITIONS
  申请人：LOCL Pharma, Inc.

  公开号：US20150290211A1

  公开（公告）日：2015-10-15

  Provided herein are methods and compositions for effective pain treatment, which also reduce or eliminate adverse effects.
• METHODS AND COMPOSITIONS FOR TREATING VASOMOTOR SYMPTOMS
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US20150272927A1

  公开（公告）日：2015-10-01

  The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.