4-(3-Fluoro-4-methylanilino)-4-oxobut-2-enoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-Fluoro-4-methylanilino)-4-oxobut-2-enoic acid
• 化学式: C₁₁H₁₀FNO₃
• 分子量: 223.2
• InChiKey: NJRMXOUAQVCPMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL ANILINE DERIVATIVES AND USE THEREOF
  申请人：NEOMICS Co, Ltd.

  公开号：US20140142333A1

  公开（公告）日：2014-05-22

  Aniline derivatives for anticancer treatment including a compound of the Formula 1, or a derivative thereof, as an active ingredient,

  苯胺衍生物用于抗癌治疗，包括作为活性成分的化合物Formula 1或其衍生物。
• [EN] NOVEL ANILINE DERIVATIVES AND USE THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE L'ANILINE ET LEUR UTILISATION
  申请人：MEDICINAL BIOCONVERGENCE RES CT

  公开号：WO2013019093A2

  公开（公告）日：2013-02-07

  The present invention relates a novel aniline derivatives for anticancer and more particularly, it relates a novel aniline derivatives for anticancer comprising compound of the Formula 1 or a derivative thereof as an active ingredient. A compound of the present invention inhibits AIMP2-DX2 which is novel anticancer target and induces apoptosis of cancer cells, thereby being effective in preventing and treating cancer. Therefore, a novel aniline derivatives of the present invention can be used for preventing and treating cancer.