9,10-dimethoxy-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 9,10-dimethoxy-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione
• 英文别名: 9,10-dimethoxy-6,6a-dihydroisoindolo[2,3-a]quinazoline-5,11-dione
• 化学式: C₁₇H₁₄N₂O₄
• 分子量: 310.309
• InChiKey: ABHXTCWVNDYPBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  靛红酸酐 在 碳酸氢铵 、 对甲苯磺酸 作用下， 以 1,4-二氧六环 、 水 、 氯苯 为溶剂， 反应 7.5h， 生成 9,10-dimethoxy-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione
  参考文献：
  名称：

  合成新型含喹唑啉的异羟肟酸作为潜在的HDAC / VEGFR抑制剂。具有吡咯烷酮开环的异常重排和含有四环的3-N-羟基喹唑啉片段的脱水

  摘要：

  开发了合成途径并获得了新的异羟肟酸作为HDAC / VEGFR2的潜在抑制剂，包括以喹唑啉酮片段为“帽”的四环。对获得的化合物进行进一步的生物学测试将为评估所选研究方向的实际前景提供机会。

  DOI：

  10.1016/j.tetlet.2019.151315

文献信息

• ISOINDOLO[2,1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS
  申请人：BASF SE

  公开号：EP2828353B1

  公开（公告）日：2016-05-18
• ISOINDOLO[2, 1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS
  申请人：BASF SE

  公开号：US20150087755A1

  公开（公告）日：2015-03-26

  The present invention relates to a composition, which comprises a) an organic material susceptible to oxidative, thermal or light-induced degradation, which is a polymer, an oligohydroxy compound, a wax, a fat or a mineral oil, with the proviso that the polymer is not a polypeptide, agar-agar or a component of agar-agar and the oligohydroxy compound is not glucose or a component of agar-agar; and b) a compound of formula (I) n is 1, 2, 3 or 4; when n is 1, R 5 is H, C 1 -C 30 -alkyl, C 3 -C 10 -cycloalkyl, C 6 -C 10 -aryl, which is unsubstituted or substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen or one phenyl, C 7 -C 13 -aralkyl, C 2 -C 22 -alkenyl, C 3 -C 12 -alkinyl, OH, C 1 -C 30 -alkyloxy, C 3 -C 10 -cycloalkyloxy, C 6 -C 12 -aryloxy, C 7 -C 13 -aralkyloxy, hydroxy-C 1 -C 8 -alkyl, carboxy-C 1 -C 12 -alkyl, C 1 -C 12 -alkoxycarbonyl-C 1 -C 12 -alkyl, C 2 -C 30 -alkyl, which is interrupted by one or more oxygen atoms, C 2 -C 16 -alkyl, which is interrupted by one sulfur atom, or NR′ 1 R′ 2 ; when n is 2, R 5 is C 1 -C 12 -alkane-diyl, C 6 -C 14 -arylene, C 4 -C 8 -cycloalkane-bis-(C 1 -C 4 -alkylene), C 6 -C 14 -arene-bis-(C 1 -C 4 -alkylene), C 4 -C 24 -alkane-diyl, which is interrupted by one or more oxygen atoms, C 4 -C 20 -alkane-diyl, which is interrupted by one or more —NH—, —N(C 1 -C 8 -alkyl)- or —N(hydroxy-C 1 -C 8 -alkyl)-, piperazine-N,N′-bis-(C 1 -C 4 -alkylene) or C 2 -C 10 -alkane-diyl, which is interrupted by one sulfur atom; R 1 to R 4 and R 6 to R 9 are each independently from each other H, C 1 -C 12 -alkyl, C 3 -C 10 -cycloalkyl, C 3 -C 22 -alkenyl, C 1 -C 12 -alkoxy, C 1 -C 12 -alkylsulfanyl, hydroxy-C 1 -C 8 -alkyl, halogen, NR″ 1 R″ 2 , NO 2 , CN, phenyl, phenyloxy or R 1 and R 2 or R 2 and R 3 or R 3 and R 4 or R 6 and R 7 or R 7 and R 8 or R 8 and R 9 are linked together to form a five- or 6-membered alicylic, aromatic or heterocyclic ring together with their 2 corresponding carbons atoms, to which they are attached.
• METHOD OF STABILIZING HALOGEN-FREE THERMOPLASTIC RECYCLATES, PLASTICS COMPOSITION, STABILIZER COMPOSITION AND USE OF THE STABILIZER COMPOSITION
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

  公开号：US20220119624A1

  公开（公告）日：2022-04-21

  The invention relates to a method of stabilizing halogen-free thermoplastic recyclates against oxidative, thermal and/or actinic degradation. The invention also relates to a correspondingly stabilized plastics composition, a stabilizer composition for stabilizing halogen-free thermoplastic recyclates and uses thereof.
• METHOD FOR STABILIZING THERMOPLASTIC RECYCLATES, STABILIZED PLASTIC COMPOSITIONS, AND MOLDING COMPOUNDS AND MOLDED PARTS PRODUCED THEREFROM
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V.

  公开号：US20220162422A1

  公开（公告）日：2022-05-26

  The invention relates to a method for stabilizing thermoplastic recyclates or previously damaged plastic materials against oxidative, thermal and/or actinic degradation. According to the claimed method, at least one substituted sugar, selected from the group consisting of at least one ester and/or ether of an alditol or cyclitol, at least one ester of a saccharic acid, at least one amide and/or substituted amine of an amine sugar, and mixtures and combinations thereof, as the stabilizing component is introduced in a thermoplastic recyclate and optionally additionally at least one primary antioxidant and/or at least one secondary antioxidant is introduced in a thermoplastic recyclate.
• US9321902B2
  申请人：——

  公开号：US9321902B2

  公开（公告）日：2016-04-26