vismiaquinone C | 132214-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: vismiaquinone C
• 英文别名: 1,8-Dihydroxy-3-methoxy-6-methyl-2-(3-methylbut-2-enyl)anthracene-9,10-dione
• CAS: 132214-89-2
• 化学式: C₂₁H₂₀O₅
• 分子量: 352.387
• InChiKey: ALEADBNEUMOAQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  vismiaquinone C 在 三氟乙酸 作用下， 以 氯仿 为溶剂， 以20 mg的产率得到vismiaquinone D
  参考文献：
  名称：

  醌类化合物和 Vismia martiana 的其他成分

  摘要：

  摘要 Vismia martiana 的茎已被证明含有谷甾醇、丹马二烯醇、桦木酸、弗里德林、丁酮、1,1',8,8'-四羟基-3,3'-二甲基-6,6'-二甲氧基-7， 7'-（反式-3-甲基-1-丁烯基）-10, 10'-联蒽酮（内消旋和±）、大黄酸、马达加斯辛、vismiaquinone B、vismiaquinone及其异构体称为vismiaquinone C，其结构显示为是 7-(3-methyl-2-butenyl)-physcion。

  DOI：

  10.1016/0031-9422(90)80218-6
• 作为产物：
  描述：

  2-氯-8-羟基-6-甲基-1,4-萘醌 、 2-isoprenyl-1,3-dimethoxy-1-trimethylsiloxy-1,3-butadiene 以 苯 为溶剂， 以35%的产率得到8-hydroxy-2-isoprenyl-1,3-dimethoxy-6-methylanthraquinone
  参考文献：
  名称：

  An integrated approach to the synthesis of contiguously substituted xanthopurpurins, pachybasins and purpurins.

  摘要：

  Alkylation, hydroxyalkylation and acylation of 3-methyl-, 3-methoxy- and 3,4-dimethoxycrotonates can be induced to occur exclusively in the alpha-Position. Conversion of the products to dienes then provides, through cycloaddition, a wide variety of substitution patterns. This approach is illustrated by simplified syntheses of a number of naturally occurring quinones and confirms the structures proposed for vismiaquinone C, 7-geranylemodin, cinnalutein, 4,5-dihydroxydigitolutein, 2-hydroxyislandicin 1-methyl ether and calyculatone 1-methyl ether.

  DOI：

  10.1016/s0040-4020(01)80322-7

文献信息

• NAGEM, TANUS JORGE;DE, JESUS FARIA TEREZINHA, PHYTOCHEMISTRY, 29,(1990) N0, C. 3362-3364
  作者：NAGEM, TANUS JORGE、DE, JESUS FARIA TEREZINHA

  DOI：——

  日期：——
• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
  申请人：Haggerty Timothy J.

  公开号：US20140335050A1

  公开（公告）日：2014-11-13

  The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer.
• An integrated approach to the synthesis of contiguously substituted xanthopurpurins, pachybasins and purpurins.
  作者：Brigitte Caron、Paul Brassard

  DOI：10.1016/s0040-4020(01)80322-7

  日期：1993.1

  Alkylation, hydroxyalkylation and acylation of 3-methyl-, 3-methoxy- and 3,4-dimethoxycrotonates can be induced to occur exclusively in the alpha-Position. Conversion of the products to dienes then provides, through cycloaddition, a wide variety of substitution patterns. This approach is illustrated by simplified syntheses of a number of naturally occurring quinones and confirms the structures proposed for vismiaquinone C, 7-geranylemodin, cinnalutein, 4,5-dihydroxydigitolutein, 2-hydroxyislandicin 1-methyl ether and calyculatone 1-methyl ether.
• Quinonoid and other constituents ofVismia martiana
  作者：Tanus Jorge Nagem、Terezinha de Jesus Faria

  DOI：10.1016/0031-9422(90)80218-6

  日期：1990.1

  Abstract The stems of Vismia martiana have been shown to contain sitosterol, dammaradienol, betulic acid, friedelin, euxanthone, 1,1′,8,8′-tetrahydroxy-3,3′-dimethyl-6,6′-dimethoxy-7,7′-( trans -3-methyl-1-butenyl)-10, 10′-bianthrone ( meso and ±), chrysophanic acid, madagascin, vismiaquinone B, vismiaquinone and its isomer called vismiaquinone C, the structure of which was shown to be 7-(3-methyl

  摘要 Vismia martiana 的茎已被证明含有谷甾醇、丹马二烯醇、桦木酸、弗里德林、丁酮、1,1',8,8'-四羟基-3,3'-二甲基-6,6'-二甲氧基-7， 7'-（反式-3-甲基-1-丁烯基）-10, 10'-联蒽酮（内消旋和±）、大黄酸、马达加斯辛、vismiaquinone B、vismiaquinone及其异构体称为vismiaquinone C，其结构显示为是 7-(3-methyl-2-butenyl)-physcion。