(+/-)-Cyclohexyl-phenyl-acetamid | 3900-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-Cyclohexyl-phenyl-acetamid
• 英文别名: cyclohexyl-phenyl-acetic acid amide；Cyclohexyl-phenyl-essigsaeure-amid；Cyclohexylphenylacetamide；2-Cyclohexyl-2-phenylacetamide
• CAS: 3900-92-3
• 化学式: C₁₄H₁₉NO
• 分子量: 217.311
• InChiKey: AWZQYZNWDPTGOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己基苯基乙腈 在 氢氧化钾 作用下， 以 乙二醇 为溶剂， 生成 (+/-)-Cyclohexyl-phenyl-acetamid
  参考文献：
  名称：

  Salmon-Legagneur,F.; Olivier,Y., Bulletin de la Societe Chimique de France, 1965, p. 640 - 644

  摘要：

  DOI：

文献信息

• ORGANIC COMPOUNDS
  申请人：Breitenstein Werner

  公开号：US20090233920A1

  公开（公告）日：2009-09-17

  The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.

  该发明涉及3,5-取代哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖肾素活性的疾病（=紊乱）；该类化合物用于制备用于治疗依赖肾素活性疾病的药物配方；该类化合物用于治疗依赖肾素活性的疾病；包括3,5-取代哌啶化合物的药物配方，和/或包括给予3,5-取代哌啶化合物的治疗方法，一种用于制造3,5-取代哌啶化合物的方法，以及其合成的新中间体和部分步骤。优选的化合物（也可以存在为盐）具有式I的结构，其中R1、R2、T、R3和R4如规范中定义。
• [EN] HETEROARYL AMIDE ANALOGUES<br/>[FR] ANALOGUES D'HÉTÉROARYLAMIDES
  申请人：NEUROGEN CORP

  公开号：WO2009023623A1

  公开（公告）日：2009-02-19

  Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: . In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

  公开了公式Ia和/或Ib的杂环酰胺类似物的化合物、药物组合物和使用方法。在某些实施例中，这些杂环酰胺类似物是多巴胺受体的激动剂和/或配体，可能有助于治疗对P2X7受体调节敏感的疾病，例如疼痛、炎症、神经系统或神经退行性疾病、心血管疾病、眼部疾病或免疫系统疾病。
• Anti-viral method
  申请人：Eli Lilly and Company

  公开号：US06060484A1

  公开（公告）日：2000-05-09

  The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.

  本发明提供了一种通过抑制病毒与宿主细胞融合来抑制包膜病毒的化合物。该病毒可以在感染细胞、易感染细胞或需要治疗的哺乳动物中被抑制。
• Urea, thiourea and guanidine compounds and their use as anti-viral agents
  申请人：ELI LILLY AND COMPANY

  公开号：EP0806205A3

  公开（公告）日：1997-11-19

  The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.

  本发明提供了一种通过抑制病毒与宿主细胞融合来抑制包膜病毒的化合物。该病毒可以在感染细胞、易感染细胞或需要治疗的哺乳动物中被抑制。
• Heteroaryl Amide Analogues
  申请人：Bakthavatchalam Rajagopal

  公开号：US20120190680A1

  公开（公告）日：2012-07-26

  Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X 7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

  本发明揭示了公式Ia和/或Ib的杂环酰胺类似物的化合物、制药组合物和使用方法：在某些实施例中，杂环酰胺类似物是多巴胺受体的激动剂和/或配体，可用于治疗对P2X7受体调节有反应的疾病，例如疼痛、炎症、神经或神经退行性疾病、心血管疾病、眼部疾病或免疫系统疾病等。